Barrett esophagus
Chromosomal instability is regarded as an underlying mechanism of neoplastic progression, integral to the clonal selection and evolution that leads to cancer.
Barrett?s esophagus can be associated with extensive instability and clonal dynamics that evolve from an initial stage characterized by small recombination-based alterations to one with larger copy change events likely associated with mitotic instability.
Molecular biology
Premalignant Barrett?s esophagus tissue progressed through three molecular stages of disease-CDKN2A(LOH) only, CDKN2A(LOH)/TP53(LOH), and CDKN2A(LOH)/TP53(LOH) with aneuploidy. (17330261)
Increases in both numbers and sizes of regions of LOH or copy number change. In the earliest CDKN2A(LOH) only samples, few regions with both copy change and LOH are detected, whereas copy loss and LOH were highly correlated in more advanced samples. These data indicate that genomic instability increases in severity and changes character during neoplastic progression. (17330261)
References
Lai LA, Paulson TG, Li X, Sanchez CA, Maley C, Odze RD, Reid BJ, Rabinovitch PS. Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH. Genes Chromosomes Cancer. 2007 Jun;46(6):532-42. PMID: 17330261
Mino-Kenudson M, Brugge WR, Puricelli WP, Nakatsuka LN, Nishioka NS, Zukerberg LR, Misdraji J, Lauwers GY. Management of Superficial Barrett?s Epithelium-Related Neoplasms by Endoscopic Mucosal Resection: Clinicopathologic Analysis of 27 Cases. Am J Surg Pathol. 2005 May;29(5):680-686. PMID: 15832094
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Sarbia M, Donner A, Franke C, Gabbert HE. Distinction between intestinal metaplasia in the cardia and in Barrett?s esophagus: the role of histology and immunohistochemistry. Hum Pathol. 2004 Mar;35(3):371-6. PMID: 15017595
Wild CP, Hardie LJ. Reflux, Barrett?s oesophagus and adenocarcinoma: burning questions. Nat Rev Cancer. 2003 Sep;3(9):676-84. PMID: 12951586
Barrett MT, Sanchez CA, Prevo LJ, Wong DJ, Galipeau PC, Paulson TG, Rabinovitch PS, Reid BJ. Evolution of neoplastic cell lineages in Barrett oesophagus. Nat Genet. 1999 May;22(1):106-9. PMID: 10319873