KRAS mutation detection; RAS testing
Definition: Colorectal cancer is ranked the third most common cancer worldwide in terms of incidence and the second in terms of mortality.
Recent advances in therapeutic approaches to colorectal cancer have identified a potential role of anti-epidermal growth factor receptor (EGFR) targeted therapies as adjuvant treatment in advanced disease.
New evidences showed that patients harboring KRAS mutations on codons 12 and 13 are not responsive to (...)
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For more information, see : http://www.humpath.com/spip.php?article1
Most recent articles
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KRAS testing
28 November 2011 -
gene copy number assessment by pyrosequencing.
25 November 2011References
Sensitive determination of BRAF copy number in clinical samples by pyrosequencing. Setty P, Gessi M, Waha A, Hammes J, El-Maarri O, Pietsch T, Waha A. Diagn Mol Pathol. 2011 Sep;20(3):148-57. PMID: #21817898# -
real-time quantitative PCR method for bacteria detection.
25 November 2011References
Establishment of a Novel Target-Based Real-Time Quantitative PCR Method for Acinetobacter baumannii Detection. Zhang L, Ding G, Wei L, Pan X, Mei L, Zhang Y, Lu Y. Diagn Mol Pathol. 2011 Dec;20(4):242-8. PMID: #22089352# -
in situ hybridization for fungi
25 November 2011fungal in situ detection; in-situ hybridization for fungi
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amplification refractory mutation system
25 November 2011wobble-enhanced ARMS
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fluorescence polarization assay
25 November 2011Currently, the most used methods for genotyping of SNPs are costly and time consuming. It is necessary to develop a method that is more accurate, cost-effective, and simple.
An improved fluorescence polarization assay based on asymmetric polymerase chain reaction hybridization for screening SNPs has been developed.
Studies show the accuracy, simplicity, and cost-effectiveness of the fluorescence polarization assay in the detection of SNPs.
In a study, the fluorescence polarization assay (...) -
CDKN2A promoter methylation
25 November 2011p16INK4a promoter methylation status
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RNA study from FFPE
25 November 2011gene expression study from FFPE
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DNA extraction from FTA paper
25 November 2011DNA Extraction From Whatman Paper
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European contacts for molecular pathology
25 November 2011gustavotapiam@hotmail.com andresabs@hotmail.com
Austria
Grünewald K, Haun M, Fiegl M, Urbanek M, Müller-Holzner E, Massoner A, Riha K, Propst A, Marth C, Gastl G. Department of Internal Medicine, University of Innsbruck, Innsbruck, Austria. kurt.grunwald@uibk.ac.at
Maj M, Wagner L. Department of Nephrology and Dialysis, Internal Medicine III, Medical University of Vienna, Vienna, Austria
Schranz M, Talasz H, Graziadei I, Winder T, Sergi C, Bogner K, Vogel W, Zoller H. Department of (...)
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