Humpath.com - Human pathology

Most recent articles

• ciliated muconodular papillary tumor

  27 March

  Ciliated muconodular papillary tumors (CMPTs)
  Ciliated muconodular papillary tumors (CMPTs) are rare peripheral nodules of the lung first described in 2002.
  Histologically, CMPTs showed glandular and/or papillary architecture, comprising a vaguely organized mixture of nonatypical ciliated columnar cells, mucous cells, and basal cells, often enveloped by copious intra-alveolar mucin.
  Micropapillary tufts of ciliated cells and seemingly discontinuous growth along alveolar walls were (...)

• pesticide-induced carcinogenesis

  24 March

  Although pesticides are subject to extensive carcinogenicity testing before regulatory approval, pesticide exposure has repeatedly been associated with various cancers. This suggests that pesticides may cause cancer via non-mutagenicity mechanisms.
  Pesticides may modify gene promoter DNA methylation levels, suggesting that epigenetic mechanisms may contribute to pesticide-induced carcinogenesis.
  Pesticides are widely used in our environment [Weichenthal et al. 2010]. Although pesticides (...)

• hepatic arteriolosclerosis

  24 March

  Hepatic arteriolosclerosis is a small-vessel complication (microangiopathy) of the liver observed mainly in patients with diabetes who also have arterial hypertension. The clinical and prognostic implications of this finding, particularly regarding liver injury, remain to be further investigated.
  Liver involvement in diabetes is well recognized in the form of steatohepatitis and glycogenic hepatopathy. More recently, sinusoidal fibrosis, even in the absence of steatosis, has also been (...)

• organum vasculosum of the lamina terminalis

  24 March

  References
  Chordoid Gliomas of the Third Ventricle Share TTF-1 Expression With Organum Vasculosum of the Lamina Terminalis. Bielle F, Villa C, Giry M, Bergemer-Fouquet AM, Polivka M, Vasiljevic A, Aubriot-Lorton MH, Bernier M, Lechapt-Zalcman E, Viennet G, Sazdovitch V, Duyckaerts C, Sanson M, Figarella-Branger D, Mokhtari K; RENOP. Am J Surg Pathol. 2015 Mar 16. PMID: #25786084#

• chordoid glioma of the third ventricle

  24 March

  References
  Chordoid Gliomas of the Third Ventricle Share TTF-1 Expression With Organum Vasculosum of the Lamina Terminalis. Bielle F, Villa C, Giry M, Bergemer-Fouquet AM, Polivka M, Vasiljevic A, Aubriot-Lorton MH, Bernier M, Lechapt-Zalcman E, Viennet G, Sazdovitch V, Duyckaerts C, Sanson M, Figarella-Branger D, Mokhtari K; RENOP. Am J Surg Pathol. 2015 Mar 16. PMID: #25786084#

• extrapulmonary lymphangioleiomyomatosis

  23 March

  Extrapulmonary lymphangioleiomyomatosis (LAM) is a rare neoplasm of spindle cells exhibiting melanocytic and myoid differentiation that arises as a mass in the mediastinum, retroperitoneum, uterine wall, and/or intraperitoneal lymph nodes.
  Many patients also have pulmonary LAM, tuberous sclerosis complex (TSC), and/or other neoplasms of the perivascular epithelioid cell tumor family.
  Clinically occult lymph node LAM can be detected during surgical staging of pelvic cancer and is not (...)

• nodal lymphangioleiomyomatosis

  23 March

  Extrapulmonary lymphangioleiomyomatosis (LAM) is a rare neoplasm of spindle cells exhibiting melanocytic and myoid differentiation that arises as a mass in the mediastinum, retroperitoneum, uterine wall, and/or intraperitoneal lymph nodes.
  Many patients also have pulmonary LAM, tuberous sclerosis complex (TSC), and/or other neoplasms of the perivascular epithelioid cell tumor family.
  Clinically occult lymph node LAM can be detected during surgical staging of pelvic cancer and is not (...)

• perineural invasion

  23 March

  References
  Perineural Invasion Is an Independent Pathologic Indicator of Recurrence in Vulvar Squamous Cell Carcinoma. Holthoff ER, Jeffus SK, Gehlot A, Stone R, Erickson SW, Kelly T, Quick CM, Post SR. Am J Surg Pathol. 2015 Mar 16. PMID: #25786085#

• EPISPOT assay

  18 March

  Protein analysis
  Another strategy for the identification of CTCs is to enumerate and analyze proteins specifically secreted by viable tumor cells (EPISPOT, EPithelial Immuno SPOT). CTCs are enriched by negative depletion and subsequently cultured on a membrane coated with antibodies that capture the secreted proteins. Afterward, the proteins are readily identifiable by immunofluorescence microscopy using fluorochrome-labeled secondary antibodies targeting the protein of interest.
  Using (...)

• avatar mouse models

  18 March

  cancer xenografts; tumor xenograft
  Open References
  Integrated next-generation sequencing and avatar mouse models for personalized cancer treatment. Garralda E, Paz K, López-Casas PP, Jones S, Katz A, Kann LM, López-Rios F, Sarno F, Al-Shahrour F, Vasquez D, Bruckheimer E, Angiuoli SV, Calles A, Diaz LA, Velculescu VE, Valencia A, Sidransky D, Hidalgo M. Clin Cancer Res. 2014 May 1;20(9):2476-84. doi:10.1158/1078-0432.CCR-13-3047 . PMID: (...)

previous page | next page