A subset of oligodendrogliomas and oligoastrocytomas has been associated with 1p/19q deletion.
Subsequently, this genetic alteration was linked to chemosensitivity and classic histology of oligodendrogliomas.
Tumoural progression includes deletions of 9p, 10q and alterations of CDKN2A. However, these (epi)genetic changes have not been associated with specific histological features.
Presence of regions of classic histology of oligodendroglioma in a tumour sample is predictive of 1p/19q deletions. (14507338)
Necrosis and/or microvascular proliferation are signs of an additional 9p deletion. (14507338)
As CDKN2A (epi)genetic alterations were found in 71% of the 1p/19q/9p-deleted oligodendrogliomas, CDKN2A may have a role in oligodendroglioma-associated microvascular proliferation. (14507338)
References
Tumour necrosis and microvascular proliferation are associated with 9p deletion and CDKN2A alterations in 1p/19q-deleted oligodendrogliomas. Godfraind C, Rousseau E, Ruchoux MM, Scaravilli F, Vikkula M. Neuropathol Appl Neurobiol. 2003 Oct;29(5):462-71. PMID: 14507338