vesical urothelial carcinoma
Urothelial carcinoma is the most common tumor of the urinary bladder, accounting for approximately 90% of tumors in this anatomical location.
Urothelial carcinoma has a propensity for divergent differentiation, with the most common variant being squamous and the next being glandular.
Variants
nested variant
inverted papilloma-like variant
micropapillary variant
microcystic variant
lymphoepithelioma-like variant
plasmacytoid/lymphoma-like variant
clear cell (glycogen-rich) variant
lipoid cell variant
with syncytiotrophoblastic giant cells
sarcomatoid urothelial carcinoma (carcinosarcoma)
small cell carcinoma
urothelial carcinoma with mixed differentiation
squamous differentiation
glandular differentiation
large cell undifferentiated carcinoma
unusual stromal reactions
- pseudosarcomatous stroma
- stromal osseous
- cartilaginous metaplasia
- steoclast-type giant cells
- prominent lymphoid infiltrate
Differential diagnosis
benign lesions
LOH
See also
urothelial carcinomas
References
Paner GP, Ro JY, Wojcik EM, Venkataraman G, Datta MW, Amin MB. Further characterization of the muscle layers and lamina propria of the urinary bladder by systematic histologic mapping: implications for pathologic staging of invasive urothelial carcinoma. Am J Surg Pathol. 2007 Sep;31(9):1420-9. PMID: #17721199
Reviews
Lopez-Beltran A, Cheng L. Histologic variants of urothelial carcinoma: differential diagnosis and clinical implications. Hum Pathol. 2006 Nov;37(11):1371-88. PMID: 16949919
Wu XR. Urothelial tumorigenesis: a tale of divergent pathways. Nat Rev Cancer. 2005 Sep;5(9):713-25. PMID: 16110317
