trisomy 8
Trisomy 8 as the sole chromosomal aberration
hematological proliferations
- myelodysplastic syndromes (10%) (17252907, 16697122)
- chronic lymphocytic leukemia (17175382, 18474297)
- idiopathic myelofibrosis (11248333)
- myeloid sarcoma (17974004, 12437650, 11697634)
- acute myeloid leukemias (AML) (5%) (16814381, 16697122)
- acute monocytic leukemia (FAB M5b) with trisomy 8
extraskeletal mesenchymal chondrosarcoma (15899388)
epithelioid smooth muscle tumor (1868039)
pediatric undifferentiated sarcoma (17350464)
NB: Trisomy 8 in acute myeloid leukemia (AML). Trisomy 8 is the most frequently observed trisomy in acute myeloid leukemia (AML) occurring as a sole karyotype abnormality or in addition to other chromosome aberrations. Trisomy 8 in AML determines no specific disease characteristic but is a disease modulating secondary event.
Trisomy 8 with associated anomalies
chronic myeloproliferative diseases (myeloid tumors) (but not found in essential thrombocythemia)
- chronic myelogenous leukemia (CML)
- polycytemia vera (PV)
- idiopathic myelofibrosis
myelodysplastic syndromes (MDS)
- refractory anemia (RA)
- refractory anemia with ring sideroblasts (RARS)
- refractory anemia with excess of blasts ± in transformation (RAEB±T)
- chronic myelomonocytic leukemia (CMML)
- acute lymphocytic leukemia (ALL)
- acute myeloid leukemias (AML)
- acute monocytic leukemia (FAB M5b) with trisomy 8
non-Hodgkin Lymphomas
chronic lymphocytic leukemia (17175382, 17074592, 18474297)
- chronic lymphocytic leukemia with isolated trisomy 8 (17175382, 18474297)
chronic lymphoproliferative diseases
- T-prolymphocytic leukaemia (exceptional)
- hepatoblastoma (15981236, 12228913, 11996790, 11943350, 10696121, 10526534)
- embryonal rhabdomyosarcoma (9973939)
- esthesioneuroblastoma (17321323, 10574242, 1756479)
- pleuropulmonary blastoma (17163790, 9050063, 11910518, 10890933, 12660036)
- Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) (11890993, 11408064, 9428352, 9166930, 8830730)
- synovial sarcoma (15325093)
- leiomyosarcomas (1796968, 2246776)
- extraskeletal mesenchymal chondrosarcoma (15899388)
- clear cell sarcoma of tendons and aponeuroses (7685631)
- alveolar soft part sarcoma (11253120, 7773967)
- pediatric undifferentiated soft tissue sarcomas (USTS) (17350464)
- myxoid liposarcoma (1993305)
See also
- tumoral trisomies
References
Pozdnyakova O, Stachurski D, Hutchinson L, Ramakrishnan S, Miron PM. Trisomy 8 in B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet. 2008 May;183(1):49-52. PMID: 18474297
Selvarajah S, Yoshimoto M, Prasad M, Shago M, Squire JA, Zielenska M, Somers GR.Characterization of trisomy 8 in pediatric undifferentiated sarcomas using advanced molecular cytogenetic techniques.Cancer Genet Cytogenet. 2007 Apr 1;174(1):35-41. PMID: 17350464
Schoch C, Kohlmann A, Dugas M, Kern W, Schnittger S, Haferlach T. Impact of trisomy 8 on expression of genes located on chromosome 8 in different AML subgroups. Genes Chromosomes Cancer. 2006 Dec;45(12):1164-8. PMID: 17001623
Dodge W, Cruz J, Zamkoff K, Hurd D, Pettenati MJ. Use of fluorescence in situ hybridization to detect minimal residual disease in hematopoietic stem cell assays from peripheral blood stem cells of 2 patients with trisomy 8 acute myeloid leukemia. Stem Cells Dev. 2004 Feb;13(1):23-6. PMID: 15068690
Batanian JR, Bridge JA, Wickert R, Vogler C, Gadre B, Huang Y. EWS/FLI-1 fusion signal inserted into chromosome 11 in one patient with morphologic features of Ewing sarcoma, but lacking t(11;22). Cancer Genet Cytogenet. 2002 Feb;133(1):72-5. PMID: 11890993
VanDevanter DR, George D, McNutt MA, Vogel A, Luthardt F. Trisomy 8 in primary esthesioneuroblastoma. Cancer Genet Cytogenet. 1991 Nov;57(1):133-6. PMID: 1756479
