t(4;19)(q35;q13)
Molecular biology
fusion gene between DUX4 at 4q35 (MIM.606009) and CIC at 19q35 (16717057)
CIC, a human homolog of Drosophila capicua which encodes a high mobility group box transcription factor, is fused to a double homeodomain gene DUX4 as a result of a recurrent chromosomal translocation t(4;19)(q35;q13).
primitive round cell sarcoma (highly malignant extraskeletal sarcoma) (8646746)
embryonal rhabdomyosarcoma (RMS) (8646746)
dedifferentiated sarcoma with both rhabdomyosarcomatous and osteosarcomatous (8646746)
See also
References
Rakheja D, Goldman S, Wilson K, Lenarsky C, Weinthal J, Schultz R. Translocation (4;19)(q35;q13.1) associated primitive round cell sarcoma: report of a case and review of the literature. Pediatr Dev Pathol. 2007 Jul 16;:1 PMID: 17990934
Kawamura-Saito M, Yamazaki Y, Kaneko K, Kawaguchi N, Kanda H, Mukai H, Gotoh T, Motoi T, Fukayama M, Aburatani H, Takizawa T, Nakamura T. Fusion between CIC and DUX4 up-regulates PEA3 family genes in Ewing-like sarcomas with t(4;19)(q35;q13) translocation. Hum Mol Genet. 2006 Jul 1;15(13):2125-37. PMID: 16717057
Richkind KE, Romansky SG, Finklestein JZ. t(4;19)(q35;q13.1): a recurrent change in primitive mesenchymal tumors? Cancer Genet Cytogenet. 1996 Mar;87(1):71-4. PMID: 8646746