t(16;16)(p13;q22)
MYH11 at 16p13 and CBFB at 16q22
acute non lymphoblastic leukaemia (ANLL) (5-10%)
- -ANLL M4 (20%)
- associated with bone marrow eosinophilia (M4Eo-ANLL)
myelodysplastic syndromes (MDS)
Rearrangements
inv(16)(p13q22)
t(16;16)(p13;q22)
del(16)(q22)
Molecular biology
CBFB/MYH11 fusion protein in acute myeloid leukemia, usually associated with bone marrow eosinophilia (M4Eo leukemia)
References
Schnittger S, Bacher U, Haferlach C, Kern W, Haferlach T. Rare CBFB-MYH11 fusion transcripts in AML with inv(16)/t(16;16) are associated with therapy-related AML M4eo, atypical cytomorphology, atypical immunophenotype, atypical additional chromosomal rearrangements and low white blood cell count: a study on 162 patients. Leukemia. 2007 Apr;21(4):725-31. PMID: 17287858
