t(11;19)(q11;q13)
Molecular biology
MALAT1/MHLB1 fusion
The breakpoint at 11q13 occurred in the MALAT1 gene, also known as ALPHA.
- MALAT1 is rearranged in renal tumors harboring the t(6;11)(p21;q13) translocation, and noncoding MALAT1 transcripts are overexpressed in a number of human carcinomas.
The breakpoint at 19q13.4 occurs at a locus we refer to as MHLB1, for Mesenchymal Hamartoma of the Liver Breakpoint 1.
- The MHLB1 locus does not contain a known gene
mesenchymal hamartoma of the liver (17311249)
embryonal sarcoma of the liver
References
Rajaram V, Knezevich S, Bove KE, Perry A, Pfeifer JD. DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation. Genes Chromosomes Cancer. 2007 May;46(5):508-13. PMID: 17311249
Rakheja D, Margraf LR, Tomlinson GE, Schneider NR. Hepatic mesenchymal hamartoma with translocation involving chromosome band 19q13.4: a recurrent abnormality. Cancer Genet Cytogenet. 2004 Aug;153(1):60-3. PMID: 15325096