t(11;17)(q23;q12-q25)
acute myeloid leukemia (AML)
The majority of translocations that involve the long arms of chromosomes 11 and 17 in acute myeloid leukemia appear identical on the cytogenetic level but they are diverse on the molecular level. Two genes are known in 11q23 and four in 17q12-25 that generate five distinct fusion genes:
MLL/MLLT6 (AF17)
MLL/LASP1
MLL/ACACA
MLL/SEPT9 (MSF)
ZBTB16/PLZF (RARA)
References
Strehl S, Konig M, Meyer C, Schneider B, Harbott J, Jager U, von Bergh AR, Loncarevic IF, Jarosova M, Schmidt HH, Moore SD, Marschalek R, Haas OA. Molecular dissection of t(11;17) in acute myeloid leukemia reveals a variety of gene fusions with heterogeneous fusion transcripts and multiple splice variants. Genes Chromosomes Cancer. 2006 Nov;45(11):1041-9. PMID: 16897742