Human pathology

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t(11;17)(q23;q12-q21)

Tumors

- acute myelocytic leukemia (AML)

Molecular biology

- fusion of MLL at 11q23 (MIM.159555) and MLLT6 (AF17) at 17q21 (MIM.600328)

References

- Prasad, R.; Leshkowitz, D.; Gu, Y.; Alder, H.; Nakamura, T.; Saito, H.; Huebner, K.; Berger, R.; Croce, C. M.; Canaani, E. : Leucine-zipper dimerization motif encoded by the AF17 gene fused to ALL-1 (MLL) in acute leukemia. Proc. Nat. Acad. Sci. 91: 8107-8111, 1994. PubMed ID : 8058765