Human pathology

Home page > G. Tumoral pathology > Cancer genetics > Cancer cytogenetics > Tumoral translocations > t(1;19)(q23;p13)

t(1;19)(q23;p13)

t(1;19)(q23;p13.3)

The t(1;19)(q23;p13.3) is one of the most common chromosomal abnormalities in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and usually gives rise to the TCF3/PBX1 fusion gene.

Tumors

- ALL (5%)

  • L1/L2 type ALL
  • L3-like ALL
  • T-ALL

- LMNH
- ANLL

Molecular biology

- PBX1E/E2A fusion gene

See also

- Oncobase