splenic hamartoma
hamartoma of the spleen, splenoma
Associations
refractory microcytic anemia
sickle cell anemia
hereditary spherocytosis
dyserythropoietic hemolytic anemia
Synopsis
one and multiple bulging nodules
nodules from 1.3 to 7 cm, indistinct from the surrounding nonlymphoid splenic (red pulp) parenchyma
red splenic pulp with variable histiocytic proliferation, focal extramedullary hematopoiesis, lympho-plasmacytosis, fibrosis, and siderotic-calcific deposits
intranodular small T- and B-cell lymphoid aggregates
no organized secondary follicles or periarteriolar sheaths
Differential diagnosis
benign vascular tumors
References
Abramowsky C, Alvarado C, Wyly JB, Ricketts R. "Hamartoma" of the Spleen (Splenoma) in Children. Pediatr Dev Pathol. 2004 Mar 25. PMID: 15037946