Uterus

• uterine mesenchymal tumors
  10 July

  Uterine mesenchymal tumors are genetically heterogenous; those with uniform cytomorphology, best exemplified by endometrial stromal tumors, often contain various fusion genes.
  Novel fusions involving ESR1 and GREB1 , key factors in sex hormone pathways, have been implicated in rare uterine mesenchymal tumors.
  Particularly, the fusions between 5’-ESR1/GREB1 and 3’-NCOA2/NCOA3 were recently identified in 4 uterine tumors resembling ovarian sex-cord tumor (...)

• GREB1-rearranged uterine sarcomas with variable sex-cord differentiation
  10 July

  Pathology
  GREB1-rearranged uterine sarcomas with variable sex-cord differentiation. Growth regulation by estrogen in breast cancer 1 / GREB1 is a protein that in humans is encoded by the GREB1 gene. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for (...)

• endometrial anomalies
  22 August 2018

  Types
  endometrial epithelial anomalies
  endometrial chorionic anomalies endometrial vascular anomalies endometrial cellualr infiltration
  See also
  endometrium

• uterine PEComa
  13 July 2018

  Uterine perivascular epithelioid cell tumors (PEComas)
  Uterine perivascular epithelioid cell tumors (PEComas) are rare neoplasms that may show overlapping morphology and immunohistochemistry with uterine smooth muscle tumors.
  Paywall references
  Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors. Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Franco Zannoni G, Carlson J, Slavik T, Tornos (...)

• endometrial giant cell carcinoma
  15 April 2018

  Endometrial carcinoma; Giant cell carcinoma
  |PO|
  Definition: Endometrial giant cell carcinoma is high grade endometrial adenocarcinomas with a malignant giant cell component and aggressive clinical course.
  See also
  endometrial carcinomas
  giant cell carcinomas

• uterine ciliated carcinoma
  15 April 2018

  PO
  Definition: Uterine ciliated carcinoma is a rare subtype of well differentiated endometrioid adenocarcinoma with good prognosis. It may derive from complex ciliated metaplasia.
  See also
  endometrial carcinomas

• endometrial clear cell carcinoma
  15 April 2018

  Clear Cell Carcinoma of Endometrium; clear cell endometrial carcinoma WP
  Definition : Clear cell carcinomas comprise about 5% of endometrial carcinomas. They consist of clear cells or hobnail cells in papillary, tubular, or solid growth patterns (shown here). The cytoplasm ranges from clear to eosinophilic. Cytologic atypia ranges from minimal to marked in different parts of the tumor.
  The tumor shows tubulo-cystic and papillary architecture in this image. The overall histologic (...)

• villoglandular endometrioid carcinoma
  15 April 2018

  Endometrioid Carcinoma - Villoglandular type WP
  Definition : This subtype of endometrioid adenocarcinoma consists of finger-like projections lined by tall columnar cells with bland nuclei. Focal villoglandular changes are seen in almost 25% of endometrioid carcinomas. Villoglandular variants have to be distinguished from the more aggressive papillary serous carcinoma.
  Images
  http://www.webpathology.com/image.asp?n=19&Case=569
  See also
  uterine endometrioid (...)

• uterine endometrioid adenocarcinoma, FIGO grade 3
  15 April 2018

  PO WP
  Definition : Grade 3 tumors contain solid areas comprising more than 50% of the tumor. They make up approximately 15% of all endometrial adenocarcinomas.
  In tumors with squamous differentiation, only the glandular component is considered for grading purposes as previously mentioned.
  See also
  uterine endometrioid adenocarcinoma

• uterine endometrioid adenocarcinoma, FIGO grade 2
  15 April 2018

  WP
  Definition: Grade 2 tumors contain 6% to 50% of solid, non-morular component.
  Grade 2 tumors make up approximately 35% of all endometrial adenocarcinomas.
  Images
  http://www.webpathology.com/image.asp?case=569&n=13
  See also
  uterine endometrioid adenocarcinoma

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