Prostate

• BRCA2-mutated prostatic adenocarcinoma
  18 January 2017

  BRCA2-associated prostate cancer; BRCA2-mutant prostatic adenocarcinoma
  Phenotype
  IDCP : intraductal carcinoma of the prostate
  Associations :
  high-grade tumor
  large tumor volume
  poor clinical outcome
  The carrier rate of germline BRCA1/2 and ATM mutation was ∼5-fold higher in lethal prostate cancer patients than in localized prostate cancer patients. doi:10.1016/j.eururo.2016.11.033.
  Mutation carriers of BRCA1/2 and ATM are associated with earlier age at death and shorter (...)

• pseudoatrophic prostatic adenocarcinoma
  2 January 2017

  Pseudoatrophic prostate cancer. pseudoatrophic prostatic carcinoma
  Images
  Pseudoatrophic prostate cancer. Note the nucleoli. https://twitter.com/IczkowskiA/status/837001964563152903
  See also
  prostatic carcinomas prostatic adenocarcinoma

• prostatic pathology
  2 January 2017

  prostate pathology; pathology of the prostate
  Links
  Webpathology
  See
  prostatic anomalies
  prostatic diseases
  prostatic tumors prostatic carcinomas

• ductal endometrioid carcinoma
  8 December 2016

  Ductal endometrioid carcinoma of prostate
  Images
  Ductal endometrioid carcinoma of prostate https://twitter.com/drshahinhameed/status/806775466384191488
  See also
  prostatic adenocarcinoma

• prostatic microcystic adenocarcinoma
  8 December 2016

  Microcystic adenocarcinoma is characterized by cystic dilatation and rounded expansion of glands of usual acinar adenocarcinoma, with a flat luminal lining layer.
  It represents a form of atrophic and/or pseudohyperplastic variants. The incidence in adenocarcinomas in whole prostate glands is approximately 11%.
  Microscopically, the mean glandular size of microcystic adenocarcinoma is 10-fold greater than that of usual small acinar adenocarcinoma. Intraluminal crystalloids and intraluminal (...)

• prostatic clear cell adenocarcinoma
  8 December 2016

  prostate clear cell adenocarcinoma PO
  There are single case reports of renal-type clear cell carcinoma, tubulocystic clear cell adenocarcinoma of the prostate, and clear cell adenocarcinoma resembling Mullerian/urethral adenocarcinoma arising in the prostatic utricle.
  Microscopy
  tubulocystic and papillary glands lined by glycogen-rich, cuboidal or hobnail cells with clear to eosinophilic cytoplasm
  enlarged nuclei with mild pleomorphism and prominent nucleoli
  may have prominent (...)

• PIN-like adenocarcinoma
  8 December 2016

  PIN-like "ductal" adenocarcinoma; PIN-like ductal adenocarcinomas
  Definition: PIN-like adenocarcinoma is a recently described growth variant of adenocarcinoma of the prostate that resembles PIN in gland architecture.
  Images
  PIN-like "ductal" adenocarcinoma
  https://twitter.com/slusagar/status/858004391323811840
  PIN-like ductal adenocarcinoma mixed with Paneth cell like carcinoma
  https://twitter.com/Andres_Matoso/status/863090582188699648
  Clinically, patients are similar to those (...)

• prostate
  8 December 2016

  normal prostate WKP
  Definition : The prostate (from Ancient Greek προστάτης, prostates, literally "one who stands before", "protector", "guardian") is a compound tubuloalveolar exocrine gland of the male reproductive system in most mammals.
  Zones
  peripheral zone (PZ) The sub-capsular portion of the posterior aspect of the prostate gland that surrounds the distal urethra. From this portion of the gland 70–80% of prostatic cancers originate.
  central zone (CZ) This zone surrounds the (...)

• prostatic pleomorphic giant cell adenocarcinoma
  8 December 2016

  This is an exceptionally rare variant of adenocarcinoma with giant pleomorphic nuclei (Figure 12).10,11 Fewer than 10 cases have been reported. In the largest series of six cases, patients ranged in age from 59 to 76 years.11 Admixed Gleason score 9 usual adenocarcinoma was seen in all cases. There was variable immunopositivity for PSA in bizarre giant cells. The disease course is very aggressive.
  Histological variants of prostatic carcinoma and their significance. Humphrey PA. (...)

• prostatic cribriform anomalies
  30 September 2016

  Prostate lesions with cribriform / pseudocribriform pattern
  Images
  cribriform glands with necrosis in prostate. Gleasons pattern 5 https://twitter.com/subteraneandoc/status/781987547664625664
  See also
  tumoral patterns / tumoral architecture
  mammary cribriform carcinomas
  gallbladder cribriform carcinomas (#18769339#)
  Open references
  Prostate lesions with cribriform / pseudocribriform pattern.
  Dema A, Borda A, Lazăr E, Lăzureanu C, Tăban S, Anderco D, Cornianu M, Mureşan A, (...)

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