Blood and immunity

• granulocytes
  29 September 2016

  granulocyte ; polymorphonuclear leukocytes (PMN, PML, or PMNL) WKPD
  Definition: Granulocytes are a category of leukocytes (white blood cells) characterized by the presence of granules in their cytoplasm.
  They are also called polymorphonuclear leukocytes (PMN, PML, or PMNL) because of the varying shapes of the nucleus, which is usually lobed into three segments. This distinguishes them from the mononuclear agranulocytes.
  In common parlance, the term polymorphonuclear leukocyte often (...)

• myeloid proliferations with germline predisposition
  28 September 2016

  myeloid Neoplasms with Germline predisposition
  WHO Classification
  Myeloid neoplasms with germline predisposition without a pre-existing disorder or organ dysfunction AML with germline CEBPA mutation Myeloid neoplasms with germline DDX41 mutation
  Myeloid neoplasms with germline predisposition and pre-existing platelet disorders Mye!oid neoplasms with germline RUNX1 mutation Myeloid neoplasms with germline ANKRD26 mutation Myeloid neoplasms with germline ETV6 mutation
  Myeloid (...)

• lymphoid anomalies
  28 September 2016

  lymphoid lesions
  Examples
  lymphoid hyperplasia

• MLL-associated leukemias
  20 May 2016

  MLL-rearranged leukemias
  Note
  CD19-negative myeloid phenotype Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. http://www.bloodjournal.org/content/127/20/2406

• therapy-related myeloid neoplasms
  11 April 2016

  t-MN
  Deletion 7q is a common chromosomal abnormality in patients with therapy-related myeloid neoplasms (t-MN). Newly emerged del(7q) in patients with prior cytotoxic therapies raises concern for t-MN.
  del(7q) emerged in patients with prior cytotoxic therapies is not always associated with t-MN. The clone size is critical. When del(7q) presents as a major clone it is often associated with t-MN; whereas when it is a minor clone it may be a transient finding and may not have any clinical (...)

• inflammatory pseudotumor-like follicular dendritic cell sarcoma
  8 April 2016

  Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant
  Open references
  Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma.
  Ge R, Liu C, Yin X, Chen J, Zhou X, Huang C, Yu W, Shen X.
  Int J Clin Exp Pathol. 2014 Apr 15;7(5):2421-9. eCollection 2014. Review.
  PMID: #24966952# (free)
  Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp.
  Pan ST, Cheng CY, Lee (...)

• heavy chain gene rearrangement detection
  14 September 2015

  Open References
  Rapid detection of immunoglobulin heavy chain gene rearrangement by PCR and melting curve analysis using combined FR2 and FR3 primers. Xu D, Yang Z, Zhang D, Wu W, Guo Y, Chen Q, Xu D, Cui W. Diagn Pathol. 2015 Aug 9;10:140. doi:10.1186/s13000-015-0370-5 . PMID: #26255311# (Free)

• CCND1-MYC double rearrangements mantle cell lymphoma
  12 October 2013

  References
  Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature. Delas A, Sophie D, Brousset P, Laurent C. Pathol Res Pract. 2013 Feb 15;209(2):115-9. doi:10.1016/j.prp.2012.12.001 . PMID: #23313364#

• germinal center-associated T cell
  24 July 2013

  germinal center-associated T cells; follicular T cells
  Immunochemistry
  Programmed death-1 (PD-1) is a marker of germinal center-associated T cells. (#16819321# )
  Open References
  Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ. Am J Surg Pathol. 2006 Jul;30(7):802-10. PMID: #16819321# (...)

• TdT+ T-lymphoblast
  24 July 2013

  TdT+ T-lymphoblastic cells; TdT+ T-lymphoblasts
  Pathology
  TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. (#23060347#)
  References
  TdT+ T-lymphoblastic populations are increased in Castleman disease, in Castleman disease in association with follicular dendritic cell tumors, and in angioimmunoblastic T-cell lymphoma. Ohgami RS, Zhao S, Ohgami JK, (...)

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