atypical lymphocyte
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mitosing atypical lymphocyte in a case of dengue , PBS https://twitter.com/Mdshaha45000788/status/783570043930021888
Home > D. General pathology > Blood and immunity
Blood and immunity
Hematologic disorders
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atypical lymphocytes
5 October 2016 -
granulocytes
29 September 2016granulocyte ; polymorphonuclear leukocytes (PMN, PML, or PMNL) WKPD
Definition: Granulocytes are a category of leukocytes (white blood cells) characterized by the presence of granules in their cytoplasm.
They are also called polymorphonuclear leukocytes (PMN, PML, or PMNL) because of the varying shapes of the nucleus, which is usually lobed into three segments. This distinguishes them from the mononuclear agranulocytes.
In common parlance, the term polymorphonuclear leukocyte often (...) -
myeloid proliferations with germline predisposition
28 September 2016myeloid Neoplasms with Germline predisposition
WHO Classification
Myeloid neoplasms with germline predisposition without a pre-existing disorder or organ dysfunction AML with germline CEBPA mutation Myeloid neoplasms with germline DDX41 mutation
Myeloid neoplasms with germline predisposition and pre-existing platelet disorders Mye!oid neoplasms with germline RUNX1 mutation Myeloid neoplasms with germline ANKRD26 mutation Myeloid neoplasms with germline ETV6 mutation
Myeloid (...) -
lymphoid anomalies
28 September 2016lymphoid lesions
Examples
lymphoid hyperplasia -
MLL-associated leukemias
20 May 2016MLL-rearranged leukemias
Note
CD19-negative myeloid phenotype Acquisition of a CD19-negative myeloid phenotype allows immune escape of MLL-rearranged B-ALL from CD19 CAR-T-cell therapy. http://www.bloodjournal.org/content/127/20/2406 -
therapy-related myeloid neoplasms
11 April 2016t-MN
Deletion 7q is a common chromosomal abnormality in patients with therapy-related myeloid neoplasms (t-MN). Newly emerged del(7q) in patients with prior cytotoxic therapies raises concern for t-MN.
del(7q) emerged in patients with prior cytotoxic therapies is not always associated with t-MN. The clone size is critical. When del(7q) presents as a major clone it is often associated with t-MN; whereas when it is a minor clone it may be a transient finding and may not have any clinical (...) -
inflammatory pseudotumor-like follicular dendritic cell sarcoma
8 April 2016Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant
Open references
Clinicopathologic characteristics of inflammatory pseudotumor-like follicular dendritic cell sarcoma.
Ge R, Liu C, Yin X, Chen J, Zhou X, Huang C, Yu W, Shen X.
Int J Clin Exp Pathol. 2014 Apr 15;7(5):2421-9. eCollection 2014. Review.
PMID: #24966952# (free)
Follicular Dendritic Cell Sarcoma of the Inflammatory Pseudotumor-like Variant Presenting as a Colonic Polyp.
Pan ST, Cheng CY, Lee (...) -
heavy chain gene rearrangement detection
14 September 2015Open References
Rapid detection of immunoglobulin heavy chain gene rearrangement by PCR and melting curve analysis using combined FR2 and FR3 primers. Xu D, Yang Z, Zhang D, Wu W, Guo Y, Chen Q, Xu D, Cui W. Diagn Pathol. 2015 Aug 9;10:140. doi:10.1186/s13000-015-0370-5 . PMID: #26255311# (Free) -
CCND1-MYC double rearrangements mantle cell lymphoma
12 October 2013References
Unusual concomitant rearrangements of Cyclin D1 and MYC genes in blastoid variant of mantle cell lymphoma: Case report and review of literature. Delas A, Sophie D, Brousset P, Laurent C. Pathol Res Pract. 2013 Feb 15;209(2):115-9. doi:10.1016/j.prp.2012.12.001 . PMID: #23313364# -
germinal center-associated T cell
24 July 2013germinal center-associated T cells; follicular T cells
Immunochemistry
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells. (#16819321# )
Open References
Programmed death-1 (PD-1) is a marker of germinal center-associated T cells and angioimmunoblastic T-cell lymphoma. Dorfman DM, Brown JA, Shahsafaei A, Freeman GJ. Am J Surg Pathol. 2006 Jul;30(7):802-10. PMID: #16819321# (...)
