PTEN-PI3K–AKT pathway
The PI3K–AKT pathway is one of the most frequently abnormal signalling pathways in EEC, often resulting from mutations in the tumour suppressor gene PTEN and activating mutations in PIK3CA.
The importance of the PI3K–PTEN–AKT survival pathway in EC raises the possibility that PI3K inhibitors may be used as potential anticancer agents. In fact, a decrease of AKT phosphorylation and increased apoptosis are seen in mutated PTEN human endometrial cancer cells in the presence (...)
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