Benign adrenocortical tumors may be associated with syndromes of virilization or feminization, but the presence of a pure adrenogenital syndrome, particularly feminization, should raise the possibility of malignancy.
Some authors, in fact, consider all feminizing cortical neoplasms to be potentiallymalignant.
Virilizing adenomas are generally larger than those found in the context of pure Cushing syndrome, and a few adenomas associated with adrenogenital syndromes have weighed up to 500g. (...)
Home > E. Pathology by systems > Endocrine system > Adrenals
Adrenals
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adrenogenital syndrome-associated
4 April 2012 -
hyperaldosteronism-associated adrenocortical adenoma
4 April 2012See also
adrenocortical adenomas -
Cushing syndrome-associated adrenal cortical adenoma
4 April 2012Cushing syndrome-associated adrenocortical adenoma
Digital case
JRC:18775 : Adrenal cortical adenoma, left, with Cushing’s syndrome (F 43 y/o)
Definition: Tumors associated with Cushing syndrome are typically unilateral and present as sharply circumscribed masses that usually weigh less than 60g and measure 3 to 4c m in average diameter.
Tumors weighing more than 100g should be examined with particular care to rule out malignancy.
On cross section, adenomas vary from yellow to brown, (...) -
adrenal cortical tumors
2 March 2012adrenocortical tumors
Images
Adrenal cortical adenoma and carcinoma
https://twitter.com/a_sleeping_dog/status/750195822805983232
Digital cases
JRC:14604 : Adrenal cortical adenoma.
JRC:14612 : Atypical adrenal cortical adenoma.
JRC:14613 : Adrenal cortical carcinoma (with Cushing syndrome)
JRC:18771 : Adrenal carcinoma (NOS)
JRC:18772 : Adrenal adenoma (NOS).
Types according to grade
adrenal cortical adenoma (ACA )
adrenal cortical carcinoma (ACC )
Types according to (...) -
oncocytic adrenal cortical carcinosarcoma
1 March 2012Adrenal cortical carcinosarcoma is a rare variant of adrenal cortical carcinoma.
Sarcomatous change in adrenal cortical carcinomas is exceptionally rare.
Definition: Adrenal cortical carcinosarcoma tends to be aggressive tumors, with locoregional recurrence and rapid metastases from the sarcomatoid component.
Variants
oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous component (#22343339#) A case of sarcoma can arise in oncocytic adrenal cortical (...) -
Cushing syndrome
8 December 2011Types
ACTH-dependent Cushing syndrome
ACTH-independent Cushing syndrome
See also
clinical syndromes -
GNAS1-associated hypercorticism
12 September 2011References
Primary Bimorphic Adrenocortical Disease: Cause of Hypercortisolism in McCune-Albright Syndrome. Carney JA, Young WF, Stratakis CA. Am J Surg Pathol. 2011 Sep;35(9):1311-26. PMID: #21836496# -
primary bimorphic adrenocortical disease
12 September 2011References
Primary Bimorphic Adrenocortical Disease: Cause of Hypercortisolism in McCune-Albright Syndrome. Carney JA, Young WF, Stratakis CA. Am J Surg Pathol. 2011 Sep;35(9):1311-26. PMID: #21836496# -
adrenal gland
9 February 2011adrenals
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pigmented nodular adrenocortical disease
3 February 2011PPNAD, primary pigmented micronodular adrenal disease, pigmented micronudular dysplasia; adrenocorticotropin-independent macronodular adrenal hyperplasia; PPAD; Primary pigmented (micronodular) adrenocortical disease
Definition: Primary pigmented nodular adrenocortical disease is a rare cause of adrenocorticotropic hormone-independent Cushing syndrome.
Molecular studies have demonstrated inactivating mutations of PRKAR1A, GNAS and PDE11A4 (PDE11A), which are key components of the cAMP (...)