Endocrine systemic anomalies

Congenital adrenal hyperplasia due to 17α-hydroxylase deficiency is an uncommon form of congenital adrenal hyperplasia resulting from a defect in the gene for the enzyme CYP17A1.
17α-hydroxylase deficiency produces decreased synthesis of both cortisol and sex steroids, with resulting increase in mineralocorticoid production.
Thus, common symptoms include mild hypocortisolism, ambiguous genitalia in genetic males or failure of the ovaries to function at puberty in genetic females, and (...)

The term carcinoid syndrome refers to a constellation of symptoms mediated by various humoral factors, namely, serotonin and the tachykinins, elaborated by carcinoid tumors.
Carcinoid syndrome is most likely from metastases of a midgut (jejunum, ileum, ascending colon and appendix) tumor to the liver. Hindgut and foregut carcinoids rarely cause carcinoid syndrome. The frequency of carcinoids is GI > pulmonary. Within the GI tract, the frequency is small intestine > rectum > appendix > (...)