Definition: BLIDC are not rigidly defined, usually positive for CK5/6, CK14 or CK17, and triple negative (ER-, PR-, HER2-), often positive for EGFR. Original definition based on gene expression profile (Nature 2000;406:747, Proc Natl Acad Sci USA 2001;98:10869). These tumors are clinically heterogeneous.
BLIDC is generally considered to not be comparable to triple negative tumors by immunostains (Clin Cancer Res 2008;14:1368, Med Mol Morphol 2009;42:128) but see Breast Cancer Res (...)
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Definition: Pulmonary adenofibroma is a rare benign biphasic tumor of the lung composed of epithelial and stromal components. Pulmonary adenofibromas have variously been interpreted as hamartomas or as pseudopapillary variants of solitary fibrous tumour.
These are tumours of middle aged adults.
These are solitary peripheral "coin" lesions.
There are large pseudopapillae covered by bland cuboidal epithelium. The stroma is fibrous, containing bland spindle (...)
Lower anogenital tract
Human papillomavirus (HPV) infection of the lower anogenital tract (LAT) has long been implicated in the precancerous and cancerous lesions of the epithelia of those organs.
HPV DNA is identified in almost all cervical cancer cases.
Different HPV subtypes were found to have a different carcinogenic potential and are generally classified into two different categories: low-risk (HPV 6 and 11 cause up 90% of genital warts), and high-risk (HPV 16 and 18 associated with (...)
familial pancreatic cancer
Familial pancreatic cancer (FPC) represents 9% of PC, and the risk of malignancy in kindred does not appear to be confined to the pancreas. (#25313458#) Genetic risk factors are believed to play a major role. Approximately 10% of PC is estimated to have familial inheritance.
Subsets of familial pancreatic cancer involve germline cationic trypsinogen or PRSS1 mutations (hereditary pancreatitis), BRCA2 mutations (usually in association with hereditary (...)
Cerivastatin (1998 - removed)
histologic growth patterns in pleura
epitheloid tumors papillary tumors acinar tumors
fusiform cell tumors
The spectrum of histologic growth patterns in benign and malignant fibrous tumors of the pleura.Moran CA, Suster S, Koss MN. Semin Diagn Pathol. 1992 May;9(2):169-80. PMID: #1609159#
Spindle cell tumors of the pleura: differential diagnosis. Rdzanek M, Fresco R, Pass HI, Carbone M. Semin Diagn Pathol. 2006 Feb;23(1):44-55. PMID: #17044195#
Pleomorphic lobular carcinoma
Pleomorphic lobular carcinoma (PLC) is a subtype of infiltrating lobular carcinoma because of its dyscohesiveness, linear infiltration pattern, and lack of membranous E-cadherin staining.
However, it differs from classic lobular carcinoma because of its high-grade cytology and more aggressive clinical behavior.
In breast fine-needle aspiration biopsies, PLC can be confused with invasive ductal carcinoma, particularly the apocrine variant.
Metastatic PLC (...)
Metastatic signet-ring cell carcinoma of unknown primary origin.
Metastatic signet-ring cell carcinoma of unknown primary origin. Gregoire C, Muller G, Machiels JP, Goeminne JC. Acta Clin Belg. 2014 Apr;69(2):135-8. doi:10.1179/0001551213Z.0000000002 . PMID: #24724758#
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