Definition: Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm, representing as less than 0.5% of all non-Hodgkin’s lymphoma. It is a malignant proliferation of cells presenting morphologic and immunophenotypic characteristics of mature tissue histiocytes.
HS is known to often present as localized disease confined to the intestinal tract, skin, lymph node, or soft tissues, however, primary HS of the (...)
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The spleen develops from progenitor cells within the dorsal mesogastrium adjacent to stomach and pancreas.
The process is controlled by a number of transcription factors expressed by early spleen mesenchymal cells. These include Nkx2.3, Nkx3.3, Pbx1, Sox11, Tcf21, Tlx1 and WT1.
Mouse studies have shown that absence of any of these factors lead to either complete splenic agenesis or marked hypolasia indicating a very complex regulation of splenic development. In humans (...)
spleen disease; spleen diseases
splenic vascular tumors
Primary vascular neoplasms of the spleen constitute the majority of non-hematolymphoid splenic tumors.
The benign primary vascular tumors include hemangioma, hamartoma, and lymphangioma, whereas those of variable or uncertain biologic behavior include littoral cell angioma, hemangioendothelioma, and hemangiopericytoma.
The primary malignant vascular neoplasm of the spleen is angiosarcoma.
Peliosis is a rare lesion of unknown cause that is usually found (...)
splenic cords; Billroth cords
Definition: The Cords of Billroth (also known as splenic cords or red pulp cords) are found in the splenic red pulp between the sinusoids (splenic sinuses), consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages.
These cords contain half of the human body’s monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing.
Erythrocytes pass (...)
splenic genetic diseases splenic metabolic diseases
splenic dysimmune diseases
splenic tumors and splenic tumoral infiltrations
splenic morphological anomalies (splenic lesions)
poorly differentiated tumours in the lung
The challenge of classifying poorly differentiated tumours in the lung. Wallace WA. Histopathology. 2009 Jan;54(1):28-42. doi: 10.1111/j.1365-2559.2008.03181.x. PMID: #19187178#
The challenge of classifying poorly differentiated tumours in the lung. Wallace WA. Histopathology. 2009 Jan;54(1):28-42. doi: 10.1111/j.1365-2559.2008.03181.x. PMID: (...)
inflammatory pleural effusion
neutrophilic pleural effusion
eosinophilic pleural effusion
lymphocytic pleural effusion
histiocytic pleural effusion
tumoral pleural effusion
Immunohistochemical distinction between mesothelial and adenocarcinoma cells in serous effusions: a combination panel-based approach with a brief review of the literature. Murugan P, Siddaraju N, Habeebullah S, Basu D. Indian J Pathol Microbiol. 2009 Apr-Jun;52(2):175-81. PMID: (...)
pleural follicular lymphoid hyperplasia
pleural lymphoid hyperplasia
BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21.
Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms.
Germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and "melanocytic BAP1-mutated atypical intradermal tumors" (MBAITs), and possibly by other cancers.
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