Humpath.com - Human pathology

Most recent articles

• splenic histiocytic sarcoma

  18 May

  Digital slides
  http://www.diagnosticpathology.diagnomx.eu/vs/1009474924812827
  Definition: Histiocytic sarcoma (HS) is a rare hematopoietic neoplasm, representing as less than 0.5% of all non-Hodgkin’s lymphoma. It is a malignant proliferation of cells presenting morphologic and immunophenotypic characteristics of mature tissue histiocytes.
  HS is known to often present as localized disease confined to the intestinal tract, skin, lymph node, or soft tissues, however, primary HS of the (...)

• splenic development

  18 May

  spleen development
  The spleen develops from progenitor cells within the dorsal mesogastrium adjacent to stomach and pancreas.
  The process is controlled by a number of transcription factors expressed by early spleen mesenchymal cells. These include Nkx2.3, Nkx3.3, Pbx1, Sox11, Tcf21, Tlx1 and WT1.
  Mouse studies have shown that absence of any of these factors lead to either complete splenic agenesis or marked hypolasia indicating a very complex regulation of splenic development. In humans (...)

• splenic diseases

  18 May

  spleen disease; spleen diseases
  Links
  http://www.esp-pathology.org/pdf/hematopathology.pdf

• splenic vascular tumors

  18 May

  splenic vascular tumors
  Primary vascular neoplasms of the spleen constitute the majority of non-hematolymphoid splenic tumors.
  The benign primary vascular tumors include hemangioma, hamartoma, and lymphangioma, whereas those of variable or uncertain biologic behavior include littoral cell angioma, hemangioendothelioma, and hemangiopericytoma.
  The primary malignant vascular neoplasm of the spleen is angiosarcoma.
  Peliosis is a rare lesion of unknown cause that is usually found (...)

• splenic cord

  18 May, by Admin

  splenic cords; Billroth cords
  WP
  Definition: The Cords of Billroth (also known as splenic cords or red pulp cords) are found in the splenic red pulp between the sinusoids (splenic sinuses), consisting of fibrils and connective tissue cells with a large population of monocytes and macrophages.
  These cords contain half of the human body’s monocytes as a reserve so that after tissue injury these monocytes can move in and aid locally sourced monocytes in wound healing.
  Erythrocytes pass (...)

• splenic diseases

  18 May

  splenic disease
  WP
  Types
  splenic malformations
  splenic genetic diseases splenic metabolic diseases
  splenic dysimmune diseases
  splenic infections
  splenic tumors and splenic tumoral infiltrations
  See also
  splenic morphological anomalies (splenic lesions)

• pulmonary poorly differentiated tumors

  18 May

  poorly differentiated tumours in the lung
  References
  The challenge of classifying poorly differentiated tumours in the lung. Wallace WA. Histopathology. 2009 Jan;54(1):28-42. doi: 10.1111/j.1365-2559.2008.03181.x. PMID: #19187178#
  The challenge of classifying poorly differentiated tumours in the lung. Wallace WA. Histopathology. 2009 Jan;54(1):28-42. doi: 10.1111/j.1365-2559.2008.03181.x. PMID: (...)

• pleural effusion

  17 May

  Types
  inflammatory pleural effusion
  neutrophilic pleural effusion
  eosinophilic pleural effusion
  lymphocytic pleural effusion
  histiocytic pleural effusion
  tumoral pleural effusion
  Open references
  Immunohistochemical distinction between mesothelial and adenocarcinoma cells in serous effusions: a combination panel-based approach with a brief review of the literature. Murugan P, Siddaraju N, Habeebullah S, Basu D. Indian J Pathol Microbiol. 2009 Apr-Jun;52(2):175-81. PMID: (...)

• pleural nodular lymphoid hyperplasia

  17 May

  pleural follicular lymphoid hyperplasia
  See also
  pleural lymphoid hyperplasia

• BAP1 cancer syndrome

  17 May

  BRCA1-associated protein 1 (BAP1) is a tumor suppressor gene located on chromosome 3p21.
  Germline BAP1 mutations have been recently associated with an increased risk of malignant mesothelioma, atypical melanocytic tumors and other neoplasms.
  Germline BAP1 mutations are associated with a novel cancer syndrome characterized by malignant mesothelioma, uveal melanoma, cutaneous melanoma and "melanocytic BAP1-mutated atypical intradermal tumors" (MBAITs), and possibly by other cancers.
  MBAITs (...)

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