Skin

• acral Spitz nevi
  30 April

  Spitz nevi on acral sites are rare and poorly documented. The combination of Spitzoid cytomorphology and atypical architectural features of the junctional component may lead to an erroneous diagnosis of melanoma.
  Acral Spitz nevi is characterized by strong and diffuse P16 and P21 expression, which differs from acral nevi and acral lentiginous melanoma.
  Acral Spitz nevi are a distinctive subgroup of Spitz nevi with benign behavior.
  Awareness of the subtle histologic differentiating (...)

• eosinophilic skin diseases
  13 March

  eosinophilic dermatoses
  Definition: Eosinophilic skin diseases, commonly termed as eosinophilic dermatoses, refer to a broad spectrum of skin diseases characterized by eosinophil infiltration and/or degranulation in skin lesions, with or without blood eosinophilia.
  The majority of eosinophilic dermatoses lie in the allergy-related group, including allergic drug eruption, urticaria, allergic contact dermatitis, atopic dermatitis, and eczema.
  Parasitic infestations, arthropod bites, and (...)

• multiple nevi lipomatosis cutaneous superficialis
  3 March

  Hamartome lipomateux superficiel de Hoffmann-Zurhelle; Nevus lipomatosis cutaneous superficialis of Hoffmann-Zurhelle; multiple nevi lipomatosis cutaneous superficialis of Hoffmann-Zurhelle
  Nevus lipomatosus cutaneous superficialis (NLCS) is a rare hamartomatous skin lesion histologically characterised by the presence of mature fat tissue within the dermis.
  Clinically, two types of NLCS can be distinguished:
  a multiple type of Hoffmann-Zurhelle
  a solitary type.
  Histologically, the (...)

• eyeliner sign
  27 December 2017

  Definition: “Eyeliner sign” is seen in squamous cell carcinoma in situ. Atypical keratinocytes fill epidermis but spare basal layer (line of normal basal keratinocytes under the atypical ones resembles eyeliner 👁).
  Melanoma in situ does not have this pattern.
  Images
  “Eyeliner sign” is seen in squamous cell carcinoma in situ. https://twitter.com/JMGardnerMD/status/945671045452836870

• hidradenitis
  18 July 2017

  Images
  Hidradenitis suppurativa. Sinus tract opens to the surface, inflamed granulation tissue, mixed inflammation with abscess formation, scarring.
  Examples
  hidradenitis suppurativa

• lichen planus pemphigoides
  6 July 2017

  Images
  lichen planus (clinically and histologically) + bullous pemphigoides = lichen planus pemphigoides : extensive subepidermal clefting and eosinophils are a clue to diagnosis. https://twitter.com/DrZembowicz/status/882695037225762816

• cutaneous pleomorphic spindle cell tumors
  4 July 2017

  pleomorphic spindle cell skin tumors; pleomorphic spindle cell tumors of the skin
  Videos
  atypical fibroxanthoma (AFX) vs other cutaneous pleomorphic spindle cell tumors https://youtu.be/zdWFmSoouXM

• hypertrophic lichen sclerosus
  28 June 2017

  Images
  Hypertrophic lichen sclerosus https://twitter.com/LinskeyKaty/status/879496539785318400
  See also
  lichen sclerosus

• sclerodermoid GVHD
  25 June 2017

  Images
  Sclerodermoid GVHD https://twitter.com/FungMaxwell/status/878492468487929858 https://twitter.com/FungMaxwell/status/878491601475035136
  See also
  GVH / GVHD
  sclerodermoid anomalies

• cutaneous myxoma
  21 June 2017

  superficial angiomyxoma WKP
  Definition: A cutaneous myxoma, a.k.a. superficial angiomyxoma, consists of a multilobulated myxoid mass containing stellate or spindled fibroblasts with pools of mucin forming cleft-like spaces. There is often a proliferation of blood vessels and an inflammatory infiltrate.
  Immunostaining is positive for vimentin, negative for cytokeratin and desmin, and variable for CD34, Factor VIIIa, SMA, MSA and S-100.
  Clinically, it may present as solitary or (...)

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