A. Molecular pathology

• NEK3
  27 January 2017

  WKP
  Serine/threonine-protein kinase Nek3 is an enzyme that in humans is encoded by the NEK3 gene. It is a member of the NEKs protein family.
  In Aspergillus nidulans, lack of the serine/threonine kinase NimA (never in mitosis A) results in cell cycle arrest in G2, while overexpression causes the premature onset of mitotic events.
  The protein encoded by this gene is similar in sequence to the Aspergillus nidulans protein and may therefore play a role in mitotic regulation.
  However, the (...)

• NEK1
  27 January 2017

  Examples
  NEK1 NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation.
  Pathology defects in this gene can be a cause of polycystic kidney disease. NEK1 is thought to be involved in amytrophic lateral sclerosis.
  See also
  NEKs : NEK1 NEK2 (...)

• NEKs
  27 January 2017

  Members
  NEK1 NEK2 NEK3
  Examples
  NEK1 NIMA (never in mitosis gene a)-related kinase 1, also known as NEK1, is a human gene highly expressed in germ cells and thought to be involved in meiosis. It is also involved in the response to DNA damage from radiation; defects in this gene can be a cause of polycystic kidney disease. NEK1 is thought to be involved in amytrophic lateral (...)

• TRAP1
  26 January 2017

  WKP
  Definition: The marker tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial heat shock protein.
  Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene. TRAP1 has been shown to interact with EXT2 , EXT1 and Retinoblastoma protein RB / RB1.
  Pathology
  Colorectal cancer TRAP1 has been related to drug resistance and protection from apoptosis in colorectal cancer. Overexpression of TRAP1 might contribute to tumor (...)

• ADARs
  26 January 2017

  ADAR1 ADAR2 WKP
  Definition: Double-stranded RNA-specific adenosine deaminase is an enzyme that in humans is encoded by the ADAR gene (which stands for adenosine deaminase acting on RNA). See ADAR1 ADAR2
  Adenosine deaminases acting on RNA (ADAR) are enzymes responsible for binding to double stranded RNA (dsRNA) and converting adenosine (A) to inosine (I) by deamination.
  ADAR protein is a RNA-binding protein, which functions in RNA-editing through post-transcriptional modification of (...)

• SENSs
  26 January 2017

  Members : SESN1 , SESN2
  The Sestrins constitute a family of evolutionarily-conserved stress-inducible proteins that suppress oxidative stress and regulate adenosine monophosphate-dependent protein kinase (AMPK)- mammalian target of rapamycin (mTOR) signaling.
  By virtue of these activities, the Sestrins (SESNs) serve as important regulators of metabolic homeostasis. Accordingly, inactivation of Sestrin genes in invertebrates resulted in diverse metabolic pathologies, including oxidative (...)

• PAKs
  26 January 2017

  Definition: PAKs is a family of serine/threonine kinases which are divided into group II (PAK1 , PAK2 and PAK3 ) and group II (PAK4 , PAK6 and PAK5/7 ).
  PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus.
  Function
  PAK4 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects directional motility, invasion, metastasis, and growth.
  Pathology
  Similar to PAK1, PAK4-signaling dependent cellular functions also regulate both physiologic and (...)

• PAK4
  26 January 2017

  WKP
  Definition: Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene.
  PAK4 is one of six members of the PAKs family of serine/threonine kinases which are divided into group II (PAK1, PAK2 and PAK3) and group II (PAK4, PAK6 and PAK5/7).
  PAK4 localizes in sub-cellular domains of the cytoplasm and nucleus.
  Function
  PAK4 regulates cytoskeleton remodeling, phenotypic signaling and gene expression, and affects directional motility, invasion, (...)

• protein structure
  23 January 2017

  protein structures WKP
  Definition: Protein structure is the three-dimensional arrangement of atoms in a protein molecule.
  Examples
  protein structures
  See also
  structure
  biological structures
  biological components
  biological functions
  structure-function relationship

• DKKs
  23 January 2017

  WKP
  Definition: There are at least 2 families of secreted inhibitors of WNT signaling:
  the secreted frizzled-related protein family (as SFRP1 ; MIM.604156 ), all of which have an N-terminal cysteine-rich domain and are transmembrane receptors;
  and the Dickkopf (German for ’big head,’ or ’stubborn’) family (as DKK1 ; MIM.605189).
  Members
  DKK1 , DKK2 , DKK3
  DKK1 Dickkopf-related protein 1 is a protein that in humans is encoded by the DKK1 gene. This gene encodes a protein that is a (...)

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