Evolutionary genetics

• molecular evolution
  3 June

  WKP
  Definition : Molecular evolution is the process of change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations.
  The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes.
  Major topics in molecular evolution concern the rates and impacts of single nucleotide changes, neutral evolution vs. natural selection, origins of new genes, the genetic nature of complex (...)

• fitness
  9 March 2010

  References
  Fitness and its role in evolutionary genetics. Orr HA. Nat Rev Genet. 2009 Aug;10(8):531-9. PMID: #19546856#

• natural selection
  7 March 2010

  Empowered by technology and sampling efforts designed to facilitate genome-wide association mapping, human geneticists are now studying the geography of genetic variation in unprecedented detail.
  With high genomic coverage and geographic resolution, these studies are identifying loci with spatial signatures of selection, such as extreme levels of differentiation and correlations with environmental variables.
  Collectively, patterns at these loci are beginning to provide new insights into (...)

• neutral theory of molecular evolution
  21 November 2006

  References
  Chamary JV, Parmley JL, Hurst LD. Hearing silence: non-neutral evolution at synonymous sites in mammals. Nat Rev Genet. 2006 Feb;7(2):98-108. PMID: #16418745#

• RNA selection pressure
  18 November 2006

  References
  Xing Y, Lee C. Alternative splicing and RNA selection pressure—evolutionary consequences for eukaryotic genomes. Nat Rev Genet. 2006 Jul;7(7):499-509. PMID: #16770337#

• ecosystems
  18 November 2006

  References
  Whitham TG, Bailey JK, Schweitzer JA, Shuster SM, Bangert RK, LeRoy CJ, Lonsdorf EV, Allan GJ, DiFazio SP, Potts BM, Fischer DG, Gehring CA, Lindroth RL, Marks JC, Hart SC, Wimp GM, Wooley SC. A framework for community and ecosystem genetics: from genes to ecosystems. Nat Rev Genet. 2006 Jul;7(7):510-23. PMID: #16778835#

• computational evolution
  18 November 2006

  References
  Banzhaf W, Beslon G, Christensen S, Foster JA, Kepes F, Lefort V, Miller JF, Radman M, Ramsden JJ. Guidelines: From artificial evolution to computational evolution: a research agenda. Nat Rev Genet. 2006 Sep;7(9):729-35. PMID: #16894364#

• artificial evolution
  18 November 2006

  References
  Banzhaf W, Beslon G, Christensen S, Foster JA, Kepes F, Lefort V, Miller JF, Radman M, Ramsden JJ. Guidelines: From artificial evolution to computational evolution: a research agenda. Nat Rev Genet. 2006 Sep;7(9):729-35. PMID: #16894364#

• chordates
  13 February 2006

  Hemichordates, the phylum of bilateral animals most closely related to chordates, could reveal the evolutionary origins of chordate traits such as the nerve cord, notochord, gill slits and tail.
  The anteroposterior maps of gene expression domains for 38 genes of chordate neural patterning are highly similar for hemichordates and chordates, even though hemichordates have a diffuse nerve-net.
  The map of dorsoventral expression domains, centered on a Bmp-Chordin axis, differs between the two (...)

• neutral theory of molecular evolution
  30 January 2006

  According to the neutral theory of molecular evolution, some classes of mutation have too small an effect on fitness to be affected by natural selection.
  References
  Chamary JV, Parmley JL, Hurst LD. Hearing silence: non-neutral evolution at synonymous sites in mammals. Nat Rev Genet. 2006 Feb;7(2):98-108. PMID: #16418745#

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