G. Tumoral pathology

• translocation-associated inflammatory myofibroblastic tumor
  24 January 2017

  Types
  A subset of ALK-negative IMTs have rearrangement of ROS1, ETV6 or NTRK3 as a possible oncogenic mechanism, and that the detection of these alterations may be of diagnostic value and helpful for determining promising therapeutic strategies.
  ALK-associated inflammatory myofibroblastic tumor / ALK
  ROS1-associated inflammatory myofibroblastic tumor / ROS1
  NTRK3-associated inflammatory myofibroblastic tumor / NTRK3
  ETV6-associated inflammatory myofibroblastic tumor / ETV6 (...)

• HPV-associated adenocarcinoma
  20 January 2017

  Images
  Human papillomavirus positive adenocarcinoma, base of tongue, H&Es, p16, HPV ISH https://twitter.com/chioseasi/status/710487503464210432 https://twitter.com/chioseasi/status/811757980941160449 https://twitter.com/chioseasi/status/854508065193947137
  Localization
  lingual HPV-associated adenocarcinoma
  See also
  HPV-associated squamous cell carcinoma
  HPV-associated tumors
  Open references
  Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially (...)

• HPV-associated tumors
  20 January 2017

  Images
  Human papillomavirus positive adenocarcinoma, base of tongue, H&Es, p16, HPV ISH https://twitter.com/chioseasi/status/710487503464210432 https://twitter.com/chioseasi/status/811757980941160449
  Types
  HPV-associated squamous cell carcinoma
  HPV-associated adenocarcinoma
  Open references
  Human papillomavirus-associated adenocarcinoma of the base of tongue: potentially actionable genetic changes. Chang AM, Nikiforova MN, Johnson JT, Bauman JE, Perez-Ordonez B, Seethala RR, (...)

• angioleiomyoma
  20 January 2017

  WKP PO
  Definition: Angioleiomyoma (vascular leiomyoma, angiomyoma) of the skin or soft tissues is thought to arise from vascular smooth muscle, and is generally acquired.
  Images
  Vascular leiomyoma, "Angioleiomyoma"/ H palate. well circumscribed, whorled smooth ms bundles+ thick-walled BV https://twitter.com/yasserdent/status/809090641825300480
  Localization
  cutaneous angioleiomyoma
  dural angioleiomyoma
  palatine angioleiomyoma
  See also (...)

• tumoral appearance
  16 January 2017

  Types
  tumoral architecture
  tumoral cell appearance
  Examples
  small cell tumors small cell carcinomas
  See also
  tumors / Tumors

• tumoral cell appearance
  16 January 2017

  According to cell appearance
  fusiform cell tumors
  round cell tumors small round cell tumors epithelioid tumors large round cell tumors rhabdoid cell tumors
  signet ring cell tumors
  clear cell tumors
  See also
  tumors / Tumors

• epithelioid tumors
  16 January 2017

  Types
  epithelioid GIST : epithelioid gastrointestinal stromal tumor
  carcinomas
  malignant mesothelioma
  malignant melanoma / clear cell sarcoma / CCS
  gastro-intestinal neuroectodermal tumor / GNET
  epithelioid angiosarcoma / epithelioid AS / digestive EAS
  perivascular epithelioid cell tumor / digestive PEComa
  epithelioid lymphomas
  Localization - Examples
  digestive epithelioid tumors
  See also
  tumors tumoral (...)

• epithelioid inflammatory myofibroblastic sarcoma
  13 January 2017

  EIMS
  Molecular pathology
  ALK-RANBP2 fusion gene, fusing ALK and RANBP2
  Other ALK rearrangements
  Open references
  Epithelioid inflammatory myofibroblastic sarcoma: a clinicopathological, immunohistochemical and molecular cytogenetic analysis of five additional cases and review of the literature. Yu L, Liu J, Lao IW, Luo Z, Wang J. Diagn Pathol. 2016 Jul 27;11(1):67. doi:10.1186/s13000-016-0517-z.
  PMID: #27460384# Free
  A case report of epithelioid inflammatory myofibroblastic (...)

• translocation-associated soft tissue tumors
  13 January 2017

  Exemples
  alveolar rhabdomyosarcoma
  t(2;13)(q35;q14) (PAX3-FOXO1A)
  t(1;13)(p36;q14) (PAX7-FOXO1A)
  myxoid liposarcoma
  t(12;16)(q13;p11) (FUS-DDIT3)
  t(12;22)(q13;q12) (EWSR1-DDIT3)
  congenital fibrosarcoma and cellualr mesoblastic nephroma
  t(12;15)(p13;q26) (ETV6-NTRK3)
  dermatofibrosarcoma protuberans/giant cell fibroblastoma:
  t(17;22)(q22;q13) (COL1A1-PDGFB)
  alveolar soft part sarcoma
  t(X;17)(p11;q25) (TFE3-ASPL)
  synovial sarcoma
  t(X;18)((p11.2;q11.2) (SS1B-SSX1; (...)

• high-grade B-cell lymphomas
  11 January 2017

  aggressive B-cell lymphomas
  See also
  B-cell lymphomas

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