G. Tumoral pathology

• depth of invasion
  14 December 2016

  DOI
  Depth of invasion (DOI) is not tumor thickness. It is measured by perpendicular dropped down from an horizontal line at basement membrane.
  See also
  tumor thickness
  Breslow depth

• pleomorphic spindle cell sarcoma
  8 December 2016

  PSCS
  See also
  pleomorphic sarcoma
  Paywall references
  Pleomorphic spindle cell sarcoma (PSCS) formerly known as malignant fibrous histiocytoma (MFH): a complex malignant soft-tissue tumor.
  Mankin HJ, Hornicek FJ, DeLaney TF, Harmon DC, Schiller AL.
  Musculoskelet Surg. 2012 Dec;96(3):171-7. doi: 10.1007/s12306-012-0225-0.
  PMID: #23129168#

• undifferentiated pleomorphic sarcoma with giant cells
  8 December 2016

  Images
  Undifferentiated pleomorphic sarcoma with giant cells https://twitter.com/JRamirezMD/status/806137114001817601
  See also
  pleomorphic sarcoma
  Open references
  Undifferentiated pleomorphic sarcoma with osteoclast-like giant cells of the female breast. Balbi G, Di Martino L, Pitruzzella G, Pitruzzella D, Grauso F, Napolitano A, Seguino E, Gioia F, Orabona P. World J Surg Oncol. 2013 Jan 26;11:21. doi:10.1186/1477-7819-11-21.
  PMID: #23351285# (...)

• basal cell carcinomas
  8 December 2016

  Localization
  cutaneous basal cell carcinoma
  prostatic basal cell carcinoma Basal cell carcinoma of the prostate includes malignant basaloid proliferations (basaloid carcinomas) and also neoplasms that resemble, to a certain degree, adenoid cystic carcinomas of the salivary glands.
  See also
  carcinomas tumoral phenotype

• atypical spindle cell lipomatous tumor
  2 December 2016

  Identification of the neoplastic adipocytic component admixed with spindle cells, and recognition of the range of histologic appearances are key for the diagnosis of atypical spindle cell lipomatous tumor.
  Whereas the risk of metastatic dissemination is minimal, there is a non-negligible risk for local recurrence (13%) which warrants surgical resection with clear margins whenever feasible.
  See also
  atypical adipocytic tumors with spindle cell features
  low-grade lipomatous tumors (...)

• CIC-DUX4-associated round cell tumor
  2 December 2016

  CIC-DUX4 Fusion-positive Round Cell Tumor
  IHC
  DUX4 immunostaining distinguishes CIC-DUX4 tumors from other round cell mimics. Recommended use when CIC-DUX4 fusion-positive round cell tumor enters the histologic differential diagnosis. (#27879517#)
  Paywall references
  DUX4 Immunohistochemistry is a Highly Sensitive and Specific Marker for CIC-DUX4 Fusion-positive Round Cell Tumor. Siegele B, Roberts J, Black JO, Rudzinski E, Vargas SO, Galambos C. Am J Surg Pathol. 2016 Nov 22. PMID: (...)

• nodular fasciitis-like stroma
  18 November 2016

  References
  Papillary thyroid carcinoma with nodular fasciitis-like stroma and β-catenin mutations should be renamed papillary thyroid carcinoma with desmoid-type fibromatosis. 2016
  doi:10.1038/modpathol.2016.173.

• ganglion-like cells
  18 November 2016

  Images
  ganglion-like cells in proliferative myositis https://twitter.com/DrLaurenStuart/status/534754970177134594
  ganglion-like cells in proliferative fasciitis https://twitter.com/VishwasParekh/status/701774294997716992 https://twitter.com/feaselp811/status/733792267266330624
  See also
  tumoral cells tumoral cell appearance

• epithelioid tumoral cells
  16 November 2016

  epithelioid tumor cells
  Types (exemples)
  epithelioid cell histiocytoma
  vascular epithelioid cell tumor / epithelioid vascular tumors epithelioid hemangioma epitheloid Hemangioendothelioma (EHE)
  perivascular epithelioid cell tumor
  epithelioid trophoblastic tumor
  epithelioid glioblastoma
  epithelioid sarcomas epithelioid sarcoma sclerosing epithelioid fibrosarcoma
  epithelioid blue nevus
  Examples
  epithelioid cell histiocytoma : Symmetric, collarette, FXIIIa+ ALK+, ALK (...)

• liposarcoma with leiomyosarcomatous differentiation
  16 November 2016

  Dedifferentiated Liposarcoma with Leiomyosarcomatous Differentiation
  Images
  DEDIFFERENTIATED LIPOSARCOMA WITH HETEROLOGOUS LEIOMYOSARCOMATOUS DIFFERENTIATION. NB: key to dx often in peripheral fat https://twitter.com/histiocytosisX/status/798631371862315008
  Open References
  Retroperitoneal liposarcoma with leiomyosarcomatous differentiation. Suzuki M, Fukuchi M, Sakurai S, Naitoh H, Kiriyama S, Fukasawa T, Tabe Y, Yamauchi H, Yoshida T, Kuwano H.
  Int Surg. 2014 Jan-Feb;99(1):48-51. (...)

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