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leiomyosarcomas

Friday 27 February 2004

leiomyosarcoma

Digital case

- JRC:110 : Leiomyosarcoma of the skin.
- JRC:11650 : Leiomyosarcoma of soft tissue.
- JRC:6405 : Pulmonary leiomyosarcoma.

Immunochemistry

- smooth muscle actin+ (SMA+)
- BCL2+
- cyclin D1+/-
- CD44 (50 to 80%)
- GLUT+ (25-50%)

  • Glut1 positivity closely correlated with aggressive biologic behavior reflected by distant metastatic spread.

Localization

- cutaneous leiomyosarcoma
- subcutaneous leiomyosarcoma
- deep leiomyosarcoma (soft tissues leiomyosarcoma)
- retroperitoneal leiomyosarcoma
- vascular leiomyosarcoma
- uterine leiomyosarcoma
- gastrointestinal leiomyosarcoma
- leiomyosarcoma of external genitalia (vulva, penis) (#14707873#)

Cytogenetics

- Most karyotypes are complex and no consistent aberrations.

CGH (#12920222#)

losses 10q 13q14-q21 17p 19p
gains 1q 5p14-pter 17p

LOH

- 3p LOH (#12839673#)
- 9p LOH (9p21 LOH) (#15731925#)
- Chr.10 LOH (#10079273#)

Differential diagnosis

- fusiform cell tumors

  • smooth muscle cell tumors
  • myofibroblastic tumors

- EBV-associated smooth muscle tumors

  • EBV-associated leiomyoma
  • EBV-associated leiomyosarcoma

See also

- smooth muscle cell tumors

  • EBV-associated smooth muscle tumors
    • EBV-associated leiomyoma
    • EBV-associated leiomyosarcoma

- muscle cell tumors
- soft tissue tumors

References

- Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Beck AH, Lee CH, Witten DM, Gleason BC, Edris B, Espinosa I, Zhu S, Li R, Montgomery KD, Marinelli RJ, Tibshirani R, Hastie T, Jablons DM, Rubin BP, Fletcher CD, West RB, van de Rijn M. Oncogene. 2009 Nov 9. [Epub ahead of print] PMID: #19901961#

- Comparative immunohistochemical and molecular analysis of uterine and extrauterine leiomyosarcomas. Rao UN, Finkelstein SD, Jones MW. Mod Pathol. 1999 Nov;12(11):1001-9. PMID: #10574596#

Portfolio

  • Uterine leiomyosarcoma
  • Uterine leiomyosarcoma