Drugs

Articles

• alkylating agents
  12 March 2006

  alkylators

• bisphosphonate
  6 September 2005

  References
  Rodan GA, Reszka AA. Bisphosphonate mechanism of action. Curr Mol Med. 2002 Sep;2(6):571-7. PMID: #12243249#

• amiodarone
  24 February 2005

  Definition: Amiodarone is a potent antiarrhythmic agent.
  Images
  Amiodarone-induced change in thyroid
  https://twitter.com/aakasharmand/status/727148670987149312
  cirrhosis and amiodarone
  https://twitter.com/CArnold_GI/status/735956508492615682
  Liver injury
  Amiodarone causes elevated liver enzymes in up to 30% of patients and steatohepatitis in 1–2% of patients.
  The majority of cases display liver enzyme abnormalities within 24 h of intravenous infusion.
  Even low oral dosing (200 (...)

• statins
  9 May 2005

  Statins inhibit the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, which is required for cholesterol biosynthesis, and are beneficial in the primary and secondary prevention of cardiovascular disease. Most of the benefits of statin therapy are owing to the lowering of serum cholesterol levels.
  However, by inhibiting HMG-CoA reductase, statins can also inhibit the synthesis of isoprenoids, which are important lipid attachments for intracellular signaling molecules, such (...)

• NSAIDs
  22 November 2004

  Non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory agents (NSAIAs)

• nucleoside analogues
  27 January 2005

  Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.
  Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.
  See also
  nucleoside analogues
  mitochondrial diseases
  oxydative phosphorylation (OXPHOS (...)

• Sulindac
  31 May 2007

  Sulindac is a nonsteroidal anti-inflammatory drug.
  It has been reported to be effective in suppressing tumor growth through the induction of p21WAF1/cip1 in human, animal models of colon cancer and colon cancer cells.
  The efficiency of sulindac in the inhibition of cell proliferation (other than the induction of apoptosis) may be through the suppression of beta-catenin pathway in human breast and lung cancer cell (...)

• taxanes
  5 January 2006

  Definition : Taxanes are a class of diterpenes.
  Taxanes were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core.
  Molecules as paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
  Taxanes are important drugs in the treatment of ovarian and other cancers, but their efficacy is limited by intrinsic and acquired drug resistance.
  Resistance (...)

• artemisinins
  31 May 2006

  Combinations of an artemisinin with other antimalarial drugs are now recommended treatments for Plasmodium falciparum malaria in most endemic areas.
  Several individual molecules have been proposed as targets for artemisinins, in addition to the idea that artemisinins might have many targets at the same time.
  Artemisinins could inhibit the parasite-encoded sarco-endoplasmic reticulum Ca(2+)-ATPase (SERCA) PfATP6. A polymorphism in the gene encoding PfATP6 is associated with in vitro (...)

• acetaminophen
  30 January 2006

  Acetaminophen (Tylenol)

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