Drugs

Articles

• Sulindac
  31 May 2007

  Sulindac is a nonsteroidal anti-inflammatory drug.
  It has been reported to be effective in suppressing tumor growth through the induction of p21WAF1/cip1 in human, animal models of colon cancer and colon cancer cells.
  The efficiency of sulindac in the inhibition of cell proliferation (other than the induction of apoptosis) may be through the suppression of beta-catenin pathway in human breast and lung cancer cell (...)

• HIV integrase inhibitors
  12 June 2005

  References
  Ciuffi A, Bushman FD. Retroviral DNA integration: HIV and the role of LEDGF/p75. Trends Genet. 2006 Jul;22(7):388-95. PMID: #16730094#
  Pommier Y, Johnson AA, Marchand C. Integrase inhibitors to treat HIV/AIDS. Nat Rev Drug Discov. 2005 Mar;4(3):236-48. PMID: #15729361#

• acetaminophen
  30 January 2006

  Acetaminophen (Tylenol)

• NSAIDs
  22 November 2004

  Non-steroidal anti-inflammatory drugs, non-steroidal anti-inflammatory agents (NSAIAs)

• methotrexate
  28 November 2005

  MTX

• amiodarone
  24 February 2005

  Definition: Amiodarone is a potent antiarrhythmic agent.
  Images
  Amiodarone-induced change in thyroid
  https://twitter.com/aakasharmand/status/727148670987149312
  cirrhosis and amiodarone
  https://twitter.com/CArnold_GI/status/735956508492615682
  Liver injury
  Amiodarone causes elevated liver enzymes in up to 30% of patients and steatohepatitis in 1–2% of patients.
  The majority of cases display liver enzyme abnormalities within 24 h of intravenous infusion.
  Even low oral dosing (200 (...)

• minocycline
  15 June 2005

  minocycline-induced anomalies
  Pathology
  drug-induced hepatitis (minocycline-induced hepatitis)
  drug-induced acute hepatitis
  minocycline-induced pneumonitis
  drug-induced immune thrombocytopenic purpura (DITP) (#12848117#)
  autoimmune features
  minocycline-induced lupus
  serum anti-nuclear antibodies
  elevated immunoglobulin G
  perinuclear antineutrophilic cytoplasmic antibody (pANCA )
  lupus-like syndromes
  serum sickness
  infectious mononucleosis-like syndrome
  vasculitis (...)

• ACEIs
  22 November 2004

  angiotensin-converting enzyme inhibitors

• halothane
  14 October 2005

  Pathology
  mild form of hepatotoxicity (20%)
  halothane hepatitis halothane-associated massive hepatic necrosis (halothane fulminant hepatitis)

• disulfiram
  20 October 2003

  Microscopical synopsis
  pseudo-Lafora bodies in liver (#6307616#)

0 | 10 | 20 | 30