Drugs

Articles

• alkylating agents
  12 March 2006

  alkylators

• 5-FU
  12 March 2004

  5-fluoro-2’-deoxyuridine, 5-fluorouracil, fluorouracil

• halothane
  14 October 2005

  Pathology
  mild form of hepatotoxicity (20%)
  halothane hepatitis halothane-associated massive hepatic necrosis (halothane fulminant hepatitis)

• crizotinib
  10 June 2010

  Pfizer drug crizotinibPF-02341066 or 1066, PF-02341066, Xalkori Wikipedia
  Molecular target: ALK
  Definition: Crizotinib is an ALK inhibitor , ROS1 inhibitor and MET inhibitor .
  Crizotinib is undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, advanced non-small cell lung carcinoma (NSCLC ).
  Crizotinib is an oral ALK (anaplastic lymphoma kinase) inhibitor under study in patients with advanced NSCLC carrying the echinoderm (...)

• platinum
  12 June 2005

  The accidental discovery of the anticancer properties of cisplatin and its clinical introduction in the 1970s represent a major landmark in the history of successful anticancer drugs.
  Although carboplatin—a second-generation analogue that is safer but shows a similar spectrum of activity to cisplatin—was introduced in the 1980s, the pace of further improvements slowed for many years.
  However, in the past several years interest in platinum drugs has increased.
  Key developments include the (...)

• amiodarone
  24 February 2005

  Definition: Amiodarone is a potent antiarrhythmic agent.
  Images
  Amiodarone-induced change in thyroid
  https://twitter.com/aakasharmand/status/727148670987149312
  cirrhosis and amiodarone
  https://twitter.com/CArnold_GI/status/735956508492615682
  Liver injury
  Amiodarone causes elevated liver enzymes in up to 30% of patients and steatohepatitis in 1–2% of patients.
  The majority of cases display liver enzyme abnormalities within 24 h of intravenous infusion.
  Even low oral dosing (200 (...)

• acetaminophen
  30 January 2006

  Acetaminophen (Tylenol)

• taxanes
  5 January 2006

  Definition : Taxanes are a class of diterpenes.
  Taxanes were originally identified from plants of the genus Taxus (yews), and feature a taxadiene core.
  Molecules as paclitaxel (Taxol) and docetaxel (Taxotere) are widely used as chemotherapy agents. cabazitaxel was FDA approved to treat hormone-refractory prostate cancer.
  Taxanes are important drugs in the treatment of ovarian and other cancers, but their efficacy is limited by intrinsic and acquired drug resistance.
  Resistance (...)

• bleomycin
  8 February 2005

  Pathology
  bleomycin-induced pneumopathy
  bleomycin-induced scleroderma
  References
  Chen J, Stubbe J. Bleomycins: towards better therapeutics. Nat Rev Cancer. 2005 Feb;5(2):102-12. PMID: #15685195#

• zidovudine
  27 January 2005

  Nucleoside analogues can cause a mitochondrial myopathy with RRFs in muscle are nucleoside analogues, such as zidovudine, used in the treatment of certain human immunodeficiencies.
  Nucleoside analogues, after conversion into their active form, inhibit mitochondrial DNA polymerase-gamma and induce mtDNA depletion.
  See also
  nucleoside analogues
  mitochondrial diseases
  oxydative phosphorylation (OXPHOS (...)

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