Molecular groups

Articles

• atrophins
  16 July 2003

  Members
  atrophin-1

• olfactory receptors
  22 September 2003

  The olfactory receptor (OR) genes constitute the largest gene family in mammalian genomes. Humans have >1,000 OR genes, of which only approximately 40% have an intact coding region and are therefore putatively functional.

• DEFs
  22 September 2003

  defensins

• proteoglycans
  16 September 2003

  Definition: Proteoglycans are a class of glycoproteins that are heavily glycosylated. They consist of a core protein with one or more covalently attached glycosaminoglycan (GAG) chain(s). Proteoglycans are specialized glycoproteins with heterogeneous structures that are found in all connective tissues and on cell surfaces.
  These glycosaminoglycan chains (GAGs) are long, linear carbohydrate polymers that are negatively charged under physiological conditions, due to the occurrence of sulfate (...)

• MAPs
  17 September 2003

  microtubule-associated proteins

• adenosine deaminases
  22 September 2003

  Pathology
  mutations of double-stranded RNA-specific adenosine deaminase (DSRAD) (1q21.3) in dyschromatosis symmetrica hereditaria
  See also
  activation-induced deaminase
  adenosine deaminase deficiency (ADA deficiency)
  References
  de Yebenes VG, Ramiro AR. Activation-induced deaminase: light and dark sides. Trends Mol Med. 2006 Sep;12(9):432-9. PMID: #16861038#

• integrins
  11 July 2003

  ITGs
  Definition: Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix.
  Integrins are transmembrane heterodimeric glycoproteins, made up of α chains (ITGAs) and β chains (ITGBs), that are expressed on many cell types and bind to ligands on endothelial cells, other leukocytes, and the extracellular matrix.
  Examples
  α4β7 integrin
  The β2 integrins LFA-1 and Mac-1 (CD11a/CD18 and CD11b/CD18) bind to ICAM1, and the β1 integrins (such as (...)

• COLs
  4 June 2003

  Collagen

• Lectins
  14 April 2004

  Lectins are nonenzymatic proteins present in plants and animals, which preferentially bind to specific carbohydrate structures and play an important role in cell recognition.
  Features
  DC-SIGN
  References
  van Kooyk Y, Appelmelk B, Geijtenbeek TB. A fatal attraction: Mycobacterium tuberculosis and HIV-1 target DC-SIGN to escape immune surveillance. Trends Mol Med. 2003 Apr;9(4):153-9. PMID: #12727141#
  Nangia-Makker P, Conklin J, Hogan V, Raz A. Carbohydrate-binding proteins in cancer, (...)

• ribonucleoproteins
  30 November 2003

  References
  Meister G, Eggert C, Fischer U. SMN-mediated assembly of RNPs: a complex story. Trends Cell Biol. 2002 Oct;12(10):472-8. PMID: #12441251#

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