Molecular groups

Articles

• MAPs
  17 September 2003

  microtubule-associated proteins

• olfactory receptors
  22 September 2003

  The olfactory receptor (OR) genes constitute the largest gene family in mammalian genomes. Humans have >1,000 OR genes, of which only approximately 40% have an intact coding region and are therefore putatively functional.

• DEFs
  22 September 2003

  defensins

• adhesion receptors
  17 September 2003
• adenosine deaminases
  22 September 2003

  Pathology
  mutations of double-stranded RNA-specific adenosine deaminase (DSRAD) (1q21.3) in dyschromatosis symmetrica hereditaria
  See also
  activation-induced deaminase
  adenosine deaminase deficiency (ADA deficiency)
  References
  de Yebenes VG, Ramiro AR. Activation-induced deaminase: light and dark sides. Trends Mol Med. 2006 Sep;12(9):432-9. PMID: #16861038#

• SODs
  23 September 2003

  Superoxide dismutases (SODs) are found in many cell types and convert superoxide to H2O2 (2 O2- + 2 H → H2O2 + O2).
  SODs group includes both manganese-superoxide dismutase, which is localized in mitochondria, and copper-zinc-superoxide dismutase, which is found in the cytosol.
  Members
  SOD1 (cytosolic superoxide dismutase) (21q22.1)
  SOD2 (mitochondrial superoxide dismutase) (6q25.3)
  SOD3 (extracellular superoxide dismutase) (4pter-q21)
  See also
  superoxide
  reactive oxygen species (...)

• RECQLs
  17 September 2003

  RecQ helicases

• VEGFRs
  25 September 2003

  Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis during embryogenesis, skeletal growth and reproductive functions.
  VEGF has also been implicated in pathological angiogenesis associated with tumors, intraocular neovascular disorders and other conditions.
  Non-signaling co-receptors also modulate VEGF RTK signaling. Currently, several VEGF inhibitors are undergoing clinical testing in several malignancies.
  The biological effects of VEGF are mediated (...)

• PEXs
  23 September 2003

  Members
  PEX1
  PEX2
  PEX3
  PEX4
  PEX5
  PEX6
  PEX7 - peroxin-7 - mutations in Refsum disease and rhizomelic chondrodysplasia punctata type 1
  PEX8
  PEX9
  PEX10 - peroxin-10 (MIM.602859) - Zelleweger’s syndrome complementation group 7, neonatal adrenoleukodystrophy
  PEX11
  PEX12
  PEX13
  PEX14
  PEX15
  PEX16
  PEX17
  PEX18
  PEX19
  PEX20
  PEX21
  PEX22
  PEX23
  PEX24
  PEX25
  PEX26 - peroxin-26 - (...)

• COLs
  4 June 2003

  Collagen

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