Concept

Articles

• natural history
  23 April 2005

  See also
  historia

• microscopical lesions
  7 January 2005

  histologic lesion

• cancer stem cells
  2 July 2004

  The cancer stem-cell model
  Like stem cells, cancer cells are able to proliferate indefinitely. There is increasing evidence that the clonal population of neoplastic cells exhibit marked heterogeneity with respect to proliferation and differentiation and cancer cells arise in cells with the characteristics of stem cells. This hypothesis that a subset of cells drives tumorigenesis suggests targeting elimination of stem cell-like population of cancer cells as a new therapeutic strategy.
  Most (...)

• molecular time
  1 May 2004

  References
  Blair Hedges S, Kumar S. Precision of molecular time estimates. Trends Genet. 2004 May;20(5):242-7. PMID: #15109778#
  Reisz RR, Muller J. Molecular timescales and the fossil record: a paleontological perspective. Trends Genet. 2004 May;20(5):237-41. PMID: #15109777#

• immune repertoire
  15 April 2005

  References
  Schwartz RS. Diversity of the immune repertoire and immunoregulation. N Engl J Med. 2003 Mar 13;348(11):1017-26. PMID: #12637612#

• mechanisms of disease
  11 July 2003
• transcriptional hierarchy
  19 July 2003
• autoimmunity
  16 August 2004

  Acquisition by mammals of an adaptive immune system was an evolutionary leap, but occurred at the cost of autoimmunity.
  The necessity for self-recognition was appreciated in 1900, but autoimmune disease did not become a clinical reality until the 1950s-still the perimeters are indistinct.
  Autoimmune responses recapitulate the complex events of normal immune responses but cannot shut down.
  Immune tolerance is established during repertoire development centrally in thymus or bone marrow by (...)

• anatomoclinical correlation
  11 July 2003
• transheterozygosity
  20 January 2006

  transheterozygote

0 | 10 | 20 | 30 | 40 | 50