Cellular functions

Articles

• phagocytosis
  23 April 2004

  WKP
  Definition: Phagocytosis is a specific form of endocytosis involving the vesicular internalization of solid particles, such as bacteria. It is therefore distinct from other forms of endocytosis such as pinocytosis, the vesicular internalization of various liquids, and recptor-dependent endocytosis.
  Phagocytosis involves three distinct but interrelated steps:
  (1) recognition and attachment of the particle to be ingested by the leukocyte;
  (2) its engulfment, with subsequent (...)

• cellular aging
  7 March 2004

  Cellular aging is the result of a progressive decline in the proliferative capacity and life span of cells and the effects of continuous exposure to exogenous influences that result in the progressive accumulation of cellular and molecular damage. Structural and Biochemical Changes with Cellular Aging
  A number of cell functions decline progressively with age.
  Oxidative phosphorylation by mitochondria is reduced, as is synthesis of nucleic acids and structural and enzymatic proteins, (...)

• cell cycle
  13 July 2003

  cellular cycle

• clathrin-mediated endocytosis
  1 December 2003

  Definition: Clathrin-mediated endocytosis is a vesicular transport event involved in the internalization and recycling of receptors participating in signal transduction events and nutrient import as well as in the reformation of synaptic vesicles.
  Clathrin-mediated endocytosis is the specific uptake of large extracellular molecules such as proteins, membrane localized receptors and ion-channels. These receptors are associated with the cytosolic protein clathrin, which initiates the (...)

• DNA repair
  13 July 2003

  DNA reparation, DNA damage response, gene repair

• telomere shortening
  19 July 2003

  telomere erosion, short telomeres

• cell survival
  10 November 2003

  cellular survival

• cellular interactions
  10 July 2003

  Types
  immune-cell interactions
  Pathology of cellular interactions
  References
  Friedl P, Storim J. Diversity in immune-cell interactions: states and functions of the immunological synapse. Trends Cell Biol. 2004 Oct;14(10):557-67. PMID: #15450978#

• extracellular matrix remodeling
  11 July 2003

  References
  Stamenkovic I. Extracellular matrix remodelling: the role of matrix metalloproteinases. J Pathol. 2003 Jul;200(4):448-64. PMID: #12845612#

• genomic stability
  13 July 2003

  A fundamental axiom of genetic inheritance is a requirement for exceptional genetic stability over many generations of cells and organisms. However, cells have to contend with both intracellular and extracellular environments that constantly challenge the chemical stability of the genome.
  Additionally, although normal metabolic transactions of DNA such as replication, recombination and repair are generally highly accurate, there are limits to the fidelity of these processes, so genomic (...)

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