Genomic anomalies

Articles

• copy number variants
  4 February 2007

  CNVs, copy number polymorphisms, CNV, copy number variation, copy number variations

• somatic mutations
  3 December 2003

  Pathology
  somatic mutations in tumors
  somatic mutations in diseases neurofibromatosis 1 neurofibromatosis 2 incontinentia pigmenti paroxysmal nocturnal hemoglobinuria fibrous dysplasia (activating somatic mutations of the Gs alpha gene) (#8541861#) Proteus syndrome Klippel-Trenaunay syndrome Maffuci syndrome
  News
  DNA Double Take. http://www.nytimes.com/2013/09/17/science/dna-double-take.html?_r=0
  See also
  somatic mutation detection
  References
  Dalgliesh GL, Futreal PA. The (...)

• genomic instability
  13 July 2003

  genetic instability; genome instability
  Definition: Genomic instability is considered as a significant factor in the pathogenesis of cancer.
  There are several patterns of genomic instability, which are reflections of different functional defects in the cancer cells.
  Genomic instability can be divided into 2 categories: Retour ligne manuel
  chromosomal instability (CIN) Retour ligne manuel
  microsatellite instability (MSI).
  Genetic alterations can affect the structure of chromosomes, (...)