MRGX2 is a G-protein-coupled receptor. It is specifically expressed in the sensory neurons of the human peripheral nervous system and involved in nociception.
Human evolution
MRGX2 had undergone adaptive changes in the path of human evolution, which were likely caused by Darwinian positive selection. The patterns of DNA sequence polymorphisms in human populations showed an excess of derived substitutions, which against the expectation of neutral evolution, implying that the adaptive (...)
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