Dysimmune diseases

Articles

• dermatitis herpetiformis
  29 June 2004

  herpetiform dermatitis
  Definition: Dermatitis herpetiformis is characterized by papules, vesicles, and occasional bullae on an erythematous, often urticarial base.
  Dermatitis herpetiformis is associated with gluten-sensitive enteropathy. It causes small pruritic vesicles.
  Histologically it shows papillary neutrophilic microabscesses and a mixed dermal inflammatory infiltrate. DIF shows a granular pattern of IgA in the dermal papillae.
  Digital cases
  UI:924 - Dermatitis herpetiformis (...)

• Behcet disease
  31 October 2005

  Behcet syndrome

• eosinophilic granulomatosis with polyangiitis
  8 June 2005

  allergic granulomatous vasculitis, Churg-Strauss syndrome; Churg-Strauss disease; EGPA
  Cases
  Digital Case 198 (HPC:198)
  Clinical synopsis
  fever
  cough
  expectorations
  asthenia
  bilateral pulmonary infiltrates.
  Synopsis
  eosinophilic vasculitis
  eosinophilic perimyocarditis
  eosinophilic pericardial effusion
  eosinophilic pleural effusion
  peripheral blood eosinophilia
  pulmonary anomalies pulmonary eosinophilic vasculitis eosinophilic pneumonia (pulmonary eosinophilic (...)

• Hashimoto thyroiditis
  12 January 2006

  Hashimoto’s thyroiditis; Struma lymphomatosa (lymphocytic thyroiditis); chronic lymphocytic thyroiditis, Hashimoto thyroiditis, thyroid autoimmunity
  Definition: Hashimoto thyroiditis (or chronic lymphocytic thyroiditis) is the most common cause of hypothyroidism in areas of the world where iodine levels are sufficient. It is characterized by gradual thyroid failure because of autoimmune destruction of the thyroid gland.
  Images
  Cytology FNA : (...)

• systemic lupus erythematosus
  16 October 2003

  Definition: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by autoantibodies specific for highly conserved nuclear antigens, such as double-stranded DNA, histones and ribonuclear proteins.
  Digital case
  JRC:10585 : Cutaneous lupus erythematosus.
  Images
  LE cell in peritoneal fluid : https://twitter.com/pwraess/status/732709988368416768
  The requirements for the activation and response of self-reactive B cells — the source of autoantibodies — seem to be (...)

• idiopathic thrombopenic purpura
  4 April 2006

  Digital case
  HPC:300 : Normal spleen (Idiopathic thrombopenic purpura)
  See also
  purpura

• Goodpasture syndrome
  12 May 2004

  Microscopy
  Linear IgG deposition along glomerular basement membrane by immunofluorescence.
  This type of linear deposits may also be seen along alveolar septa in the lung.
  Localization
  pulmonary Goodpasture syndrome
  renal Goodpasture syndrome
  Videos
  Pulmonary Goodpasture syndrome by Washington Deceit
  References
  Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med. 2003 Jun 19;348(25):2543-56. PMID: (...)

• ankylosing spondylitis
  17 August 2004

  Susceptibility
  major histocompatibility complex (MHC) region
  HLA B27
  rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) (Chinese)
  Locus 2q13 (IL1 cluster) (#15309690#)
  EDIL3 and HAPLN1 at 5q14.3 (rs4552569) (bone formation and cartilage development)
  ANO6 at 12q12 (rs17095830) (bone formation and cartilage development)
  2p15 (rs10865331)
  Reviews
  Sims AM, Wordsworth BP, Brown MA. Genetic (...)

• IgG4-associated disease
  19 November 2003

  hyper-IgG4 disease, IMAD, IgG4 syndrome, IgG4 disease, IgG4-associated multifocal systemic fibrosclerosis, IgG4-associated immune complex multiorgan autoimmune disease, IgG4-related plasmacytic disease, hyper-IgG4 disease, multifocal systemic fibrosclerosis (MSF), systemic multifocal fibrosclerosis, inflammatory fibrotic disease, IgG4-Related Disease; IgG4-assotiated diseases; IgG4-related disease
  Definition: The IMAD or ’hyper-IgG4 disease’ is a chronic inflammatory disease, characterized (...)

• Sweet syndrome
  29 July 2007

  Sweet disease, acute febrile neutrophilic dermatosis

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