herpetiform dermatitis
Definition: Dermatitis herpetiformis is characterized by papules, vesicles, and occasional bullae on an erythematous, often urticarial base.
Dermatitis herpetiformis is associated with gluten-sensitive enteropathy. It causes small pruritic vesicles.
Histologically it shows papillary neutrophilic microabscesses and a mixed dermal inflammatory infiltrate. DIF shows a granular pattern of IgA in the dermal papillae.
Digital cases
UI:924 - Dermatitis herpetiformis (...)
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Dysimmune diseases
Dysimmunity
Articles
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dermatitis herpetiformis
29 June 2004 -
systemic lupus erythematosus
16 October 2003Definition: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by autoantibodies specific for highly conserved nuclear antigens, such as double-stranded DNA, histones and ribonuclear proteins.
Digital case
JRC:10585 : Cutaneous lupus erythematosus.
Images
LE cell in peritoneal fluid : https://twitter.com/pwraess/status/732709988368416768
The requirements for the activation and response of self-reactive B cells — the source of autoantibodies — seem to be (...) -
IPEX syndrome
12 November 2003Definition: IPEX is a X-inked fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM.304930).
Patients typically present in infancy with severe diarrhea and failure to thrive. Most children die by 1 year of age without therapy. The diagnosis is established by genetic analysis, which often takes several weeks to complete and can sometimes delay crucial immunosuppressive treatment.
Synopsis
dysimmune enteropathy (autoimmune (...) -
primary biliary cirrhosis
13 December 2005PBC
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type 1 diabetes
25 September 2003type I diabetes
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idiopathic thrombopenic purpura
4 April 2006Digital case
HPC:300 : Normal spleen (Idiopathic thrombopenic purpura)
See also
purpura -
autoimmune lymphoproliferative syndrome
6 April 2004ALPS, Canale-Smith syndrome
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ankylosing spondylitis
17 August 2004Susceptibility
major histocompatibility complex (MHC) region
HLA B27
rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) (Chinese)
Locus 2q13 (IL1 cluster) (#15309690#)
EDIL3 and HAPLN1 at 5q14.3 (rs4552569) (bone formation and cartilage development)
ANO6 at 12q12 (rs17095830) (bone formation and cartilage development)
2p15 (rs10865331)
Reviews
Sims AM, Wordsworth BP, Brown MA. Genetic (...) -
Sweet syndrome
29 July 2007Sweet disease, acute febrile neutrophilic dermatosis
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Behcet disease
31 October 2005Behcet syndrome