Dysimmune diseases

Articles

• celiac disease
  6 April 2004

  coeliac disease; celiac sprue; gluten-sensitive enteropathy
  Definition: Celiac disease is a common autoimmune condition triggered by ingesting one of several related proteins found in wheat, barley, and rye: the gliadins, hordeins, and secalins.
  In susceptible persons, ingestion of these proteins leads to infiltration of the intestinal mucosa by both intraepithelial CD8+ lymphocytes and CD4+ lamina propria lymphocytes and, ultimately, to crypt hyperplasia and villous atrophy.
  Symptoms (...)

• systemic lupus erythematosus
  16 October 2003

  Definition: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by autoantibodies specific for highly conserved nuclear antigens, such as double-stranded DNA, histones and ribonuclear proteins.
  Digital case
  JRC:10585 : Cutaneous lupus erythematosus.
  Images
  LE cell in peritoneal fluid : https://twitter.com/pwraess/status/732709988368416768
  The requirements for the activation and response of self-reactive B cells — the source of autoantibodies — seem to be (...)

• Hashimoto thyroiditis
  12 January 2006

  Hashimoto’s thyroiditis; Struma lymphomatosa (lymphocytic thyroiditis); chronic lymphocytic thyroiditis, Hashimoto thyroiditis, thyroid autoimmunity
  Definition: Hashimoto thyroiditis (or chronic lymphocytic thyroiditis) is the most common cause of hypothyroidism in areas of the world where iodine levels are sufficient. It is characterized by gradual thyroid failure because of autoimmune destruction of the thyroid gland.
  Images
  Cytology FNA : (...)

• type 1 diabetes
  25 September 2003

  type I diabetes

• autoimmune polyglandular syndrome type 1
  16 November 2007

  autoimmune polyglandular syndrome type I, APS1, APECED

• autoimmune polyglandular syndrome type 2
  16 November 2007

  autoimmune polyglandular syndrome type II, APS2

• IgG4-associated disease
  19 November 2003

  hyper-IgG4 disease, IMAD, IgG4 syndrome, IgG4 disease, IgG4-associated multifocal systemic fibrosclerosis, IgG4-associated immune complex multiorgan autoimmune disease, IgG4-related plasmacytic disease, hyper-IgG4 disease, multifocal systemic fibrosclerosis (MSF), systemic multifocal fibrosclerosis, inflammatory fibrotic disease, IgG4-Related Disease; IgG4-assotiated diseases; IgG4-related disease
  Definition: The IMAD or ’hyper-IgG4 disease’ is a chronic inflammatory disease, characterized (...)

• ankylosing spondylitis
  17 August 2004

  Susceptibility
  major histocompatibility complex (MHC) region
  HLA B27
  rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) (Chinese)
  Locus 2q13 (IL1 cluster) (#15309690#)
  EDIL3 and HAPLN1 at 5q14.3 (rs4552569) (bone formation and cartilage development)
  ANO6 at 12q12 (rs17095830) (bone formation and cartilage development)
  2p15 (rs10865331)
  Reviews
  Sims AM, Wordsworth BP, Brown MA. Genetic (...)

• Goodpasture syndrome
  12 May 2004

  Microscopy
  Linear IgG deposition along glomerular basement membrane by immunofluorescence.
  This type of linear deposits may also be seen along alveolar septa in the lung.
  Localization
  pulmonary Goodpasture syndrome
  renal Goodpasture syndrome
  Videos
  Pulmonary Goodpasture syndrome by Washington Deceit
  References
  Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG. Alport’s syndrome, Goodpasture’s syndrome, and type IV collagen. N Engl J Med. 2003 Jun 19;348(25):2543-56. PMID: (...)

• atopic dermatitis
  12 May 2005

  Susceptibility SNPs
  rs479844 upstream of OVOL1
  rs2164983 near ACTL9 (proliferation and differentiation)
  rs2897442 in KIF3A within the cytokine cluster at 5q31.1
  FLG locus
  11q13.5
  20q13.33
  Reviews
  Williams HC. Clinical practice. Atopic dermatitis. N Engl J Med. 2005 Jun 2;352(22):2314-24. PMID: #15930422#
  Bowcock AM, Cookson WO. The genetics of psoriasis, psoriatic arthritis and atopic dermatitis. Hum Mol Genet. 2004 Apr 1;13 Spec No 1:R43-55. PMID: #14996755#
  Galli E, (...)

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