Dysimmune diseases

Articles

• dermatitis herpetiformis
  29 June 2004

  herpetiform dermatitis
  Definition: Dermatitis herpetiformis is characterized by papules, vesicles, and occasional bullae on an erythematous, often urticarial base.
  Dermatitis herpetiformis is associated with gluten-sensitive enteropathy. It causes small pruritic vesicles.
  Histologically it shows papillary neutrophilic microabscesses and a mixed dermal inflammatory infiltrate. DIF shows a granular pattern of IgA in the dermal papillae.
  Digital cases
  UI:924 - Dermatitis herpetiformis (...)

• systemic lupus erythematosus
  16 October 2003

  Definition: Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by autoantibodies specific for highly conserved nuclear antigens, such as double-stranded DNA, histones and ribonuclear proteins.
  Digital case
  JRC:10585 : Cutaneous lupus erythematosus.
  Images
  LE cell in peritoneal fluid : https://twitter.com/pwraess/status/732709988368416768
  The requirements for the activation and response of self-reactive B cells — the source of autoantibodies — seem to be (...)

• IPEX syndrome
  12 November 2003

  Definition: IPEX is a X-inked fatal disorder characterized by immune dysregulation, polyendocrinopathy, enteropathy and X-linked inheritance (MIM.304930).
  Patients typically present in infancy with severe diarrhea and failure to thrive. Most children die by 1 year of age without therapy. The diagnosis is established by genetic analysis, which often takes several weeks to complete and can sometimes delay crucial immunosuppressive treatment.
  Synopsis
  dysimmune enteropathy (autoimmune (...)

• primary biliary cirrhosis
  13 December 2005

  PBC

• type 1 diabetes
  25 September 2003

  type I diabetes

• idiopathic thrombopenic purpura
  4 April 2006

  Digital case
  HPC:300 : Normal spleen (Idiopathic thrombopenic purpura)
  See also
  purpura

• autoimmune lymphoproliferative syndrome
  6 April 2004

  ALPS, Canale-Smith syndrome

• ankylosing spondylitis
  17 August 2004

  Susceptibility
  major histocompatibility complex (MHC) region
  HLA B27
  rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) (Chinese)
  Locus 2q13 (IL1 cluster) (#15309690#)
  EDIL3 and HAPLN1 at 5q14.3 (rs4552569) (bone formation and cartilage development)
  ANO6 at 12q12 (rs17095830) (bone formation and cartilage development)
  2p15 (rs10865331)
  Reviews
  Sims AM, Wordsworth BP, Brown MA. Genetic (...)

• Sweet syndrome
  29 July 2007

  Sweet disease, acute febrile neutrophilic dermatosis

• Behcet disease
  31 October 2005

  Behcet syndrome

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