Cellular lesions

Articles

• cytoskeletal anomalies
  4 February 2006

  Abnormalities of the cytoskeleton underlie a variety of pathologic states.
  The normal cytoskeleton
  The cytoskeleton consists of microtubules (20 to 25 nm in diameter), thin actin filaments (6 to 8 nm), thick myosin filaments (15 nm), and various classes of intermediate filaments (10 nm). Several other nonpolymerized and nonfilamentous forms of contractile proteins also exist.
  Cytoskeletal abnormalities may be reflected by: (1) defects in cell function, such as cell locomotion and (...)

• cellular debris-laden macrophages
  1 December 2005

  See also
  macrophage
  starry sky appearance

• hepatocytic PAS+ non-glycogenic globules
  12 March 2007

  Periodic acid Schiff-positive non-glycogenic globules in hepatocytes

• sea-blue histiocytes
  18 January 2006

  sea blue histiocytes, histiocytes "bleu de mer", acquired lipidosis of marrow macrophages

• foamy macrophages in the spleen
  20 July 2007

  Etiology
  infections mycobacterioses Mycobacterium avium intracellulare infection (MAI infection) (Case 12002)
  metabolic diseases storage diseases
  Case records
  Case 12002 : Systemic granulomatosis in Mycobacterium avium intracellulare
  See also
  medullary macrophages
  splenic macrophages

• epithelial atypia
  9 December 2005

  Definition: Atypia of epithelial cells.
  Synopsis
  nuclear enlargment
  nuclear hyperchromasia
  nuclear pleomorphism
  anisokaryosis
  Etiology
  viral infections (viral cytopathic effect)
  tumoral process (tumoral cells)
  drugs (drug-induced cellular atypia) chemotherapy alkylating agents (cyclophosphamide, busulfan, melphalan)
  Localization
  lungs
  urinary bladder
  sinonasal tract (#11342778#)
  esophagus, stomach,intestines
  pancreas
  cervix
  uterus
  breast : mammary (...)

• intramacrophagic crystals
  2 December 2005
• filamentous nerve cell inclusions
  5 January 2005

  References
  Goedert M, Spillantini MG, Davies SW. Filamentous nerve cell inclusions in neurodegenerative diseases. Curr Opin Neurobiol. 1998 Oct;8(5):619-32. PMID: #9811617#

• rhabdomyocytic lesions
  28 May 2007

  Types (Examples)
  rhabdomyocytic steatosis
  See also
  Myocytes rhabdomyocytes

• ubiquitin-containing cellular inclusions
  9 January 2006

  Ubiquitin-containing cellular inclusions are characteristic of major neurodegenerative diseases and suggest an involvement of the ubiquitin-proteasome system.
  See also
  Cellular inclusions
  References
  Hol EM, van Leeuwen FW, Fischer DF. The proteasome in Alzheimer’s disease and Parkinson’s disease: lessons from ubiquitin B+1. Trends Mol Med. 2005 Nov;11(11):488-95. PMID: (...)

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