Cellular lesions

Articles

• cytoskeletal anomalies
  4 February 2006

  Abnormalities of the cytoskeleton underlie a variety of pathologic states.
  The normal cytoskeleton
  The cytoskeleton consists of microtubules (20 to 25 nm in diameter), thin actin filaments (6 to 8 nm), thick myosin filaments (15 nm), and various classes of intermediate filaments (10 nm). Several other nonpolymerized and nonfilamentous forms of contractile proteins also exist.
  Cytoskeletal abnormalities may be reflected by: (1) defects in cell function, such as cell locomotion and (...)

• sea-blue histiocytes
  18 January 2006

  sea blue histiocytes, histiocytes "bleu de mer", acquired lipidosis of marrow macrophages

• pseudo-Gaucher cell
  29 December 2006

  pseudo-Gaucher histiocytes, pseudo-Gaucher macrophages

• lipofuscin deposits
  8 January 2006

  Definition: Lipofuscin pigment granules represent undigested material derived from intracellular lipid peroxidation.
  Images
  Lipofuscin is the "wear-and-tear" pigment of the heart. Morphologically found at the myocytes’ nuclear "poles" https://twitter.com/MelanieBoisMD/status/807701991782842369
  Wikimedia: intestinal melanosis
  Localization
  cardiomyocytic lipofuscin deposits
  hepatocytic lipofuscin deposits
  Kupffer cells lipofuscin deposits
  lipofuscin (...)

• cholesterol crystals
  3 December 2005

  cholesterol clefts; Cholesterol crystal clefts
  Images
  aortic atherosclerotic plaque Image: https://twitter.com/BeynonMD/status/718292728862400512
  cholesterol embolism / cholesterol embolus with cholesterol clefts https://twitter.com/BethBraunhut/status/877208580209999876
  Cholesterol crystal clefts and foreing-body giant cells found in radicular cyst https://twitter.com/reportesVilla/status/879410114914136064
  See also (...)

• vacuolated Kuppfer cells
  29 July 2008

  Etiology (Examples)
  galactosialidosis (MIM.256540)

• intramacrophagic cholesterol crystals
  3 December 2005

  cholesterol crystals in macrophages

• foamy macrophages in the spleen
  20 July 2007

  Etiology
  infections mycobacterioses Mycobacterium avium intracellulare infection (MAI infection) (Case 12002)
  metabolic diseases storage diseases
  Case records
  Case 12002 : Systemic granulomatosis in Mycobacterium avium intracellulare
  See also
  medullary macrophages
  splenic macrophages

• cytoplasmic globules
  12 March 2007

  Etiology
  in diseases alpha-1-antitrypsine deficiency rete testis hyperplasia with hyaline globule formation (#1702268#)
  in tumors endodermal sinus tumor (yolk sac tumor) infantile digital fibroma vascular tumors malignant rhabdoid tumor (MRT) (#3030922#) eosinophilic intracytoplasmic globules in pulmonary adenocarcinoma(#2476374#)
  Localization
  in hepatocytes alpha-1-antitrypsine deficiency
  See also
  hyaline globules
  matrix globules
  hepatocytic PAS+ non-glycogenic (...)

• epithelial atypia
  9 December 2005

  Definition: Atypia of epithelial cells.
  Synopsis
  nuclear enlargment
  nuclear hyperchromasia
  nuclear pleomorphism
  anisokaryosis
  Etiology
  viral infections (viral cytopathic effect)
  tumoral process (tumoral cells)
  drugs (drug-induced cellular atypia) chemotherapy alkylating agents (cyclophosphamide, busulfan, melphalan)
  Localization
  lungs
  urinary bladder
  sinonasal tract (#11342778#)
  esophagus, stomach,intestines
  pancreas
  cervix
  uterus
  breast : mammary (...)

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