Abnormalities of the cytoskeleton underlie a variety of pathologic states.
The normal cytoskeleton
The cytoskeleton consists of microtubules (20 to 25 nm in diameter), thin actin filaments (6 to 8 nm), thick myosin filaments (15 nm), and various classes of intermediate filaments (10 nm). Several other nonpolymerized and nonfilamentous forms of contractile proteins also exist.
Cytoskeletal abnormalities may be reflected by: (1) defects in cell function, such as cell locomotion and (...)
Home > Keywords > Morphological anomalies > Cellular lesions
Cellular lesions
Articles
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cytoskeletal anomalies
4 February 2006 -
vacuolated Kuppfer cells
29 July 2008Etiology (Examples)
galactosialidosis (MIM.256540) -
hepatocytic PAS+ non-glycogenic globules
12 March 2007Periodic acid Schiff-positive non-glycogenic globules in hepatocytes
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lipofuscin deposits
8 January 2006Definition: Lipofuscin pigment granules represent undigested material derived from intracellular lipid peroxidation.
Images
Lipofuscin is the "wear-and-tear" pigment of the heart. Morphologically found at the myocytes’ nuclear "poles" https://twitter.com/MelanieBoisMD/status/807701991782842369
Wikimedia: intestinal melanosis
Localization
cardiomyocytic lipofuscin deposits
hepatocytic lipofuscin deposits
Kupffer cells lipofuscin deposits
lipofuscin (...) -
lipofuscin deposits in digestive smooth muscle cells
8 January 2006See also
lipofuscin deposits
digestive smooth muscle cells -
sea-blue histiocytes
18 January 2006sea blue histiocytes, histiocytes "bleu de mer", acquired lipidosis of marrow macrophages
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Rosenthal fibers
16 April 2005Rosenthal fiber inclusions
Definition: Subtype of intermediate filament inclusions formed by aggregation of glial fibrillary acidic protein (GFAP ).
Images
Incidental, but large pineal cyst. Frequent Rosenthal fibres in cyst wall are typical. https://twitter.com/neuropathobern/status/859447047677779972
Pathology
Alexander disease
pilocytic astrocytoma Image : https://twitter.com/rxmsimages/status/718719835723603968
pineal (...) -
cryptic apoptotic bodies
18 October 2004crypt apoptotic bodies; crypt apoptotic body
Images
colorectal GVHD
https://twitter.com/Pathologists/status/742099178583515137
https://twitter.com/stephen_lagana/status/736578297153327104
Histopathology assessment is crucial for the diagnosis of graft versus host disease (GVHD), as the presence of crypt apoptosis is the cardinal criterion required.
However, crypt apoptosis is not limited to GVHD; it also occurs in other conditions such as infection, drug reaction, or inflammatory (...) -
biliary epithelial dysplasia
29 August 2008Etiology
Clonorchis sinensis
choledochal cyst
gallbladder dysplasia
See also
biliary epithelial lesions -
cholesterol crystals
3 December 2005cholesterol clefts; Cholesterol crystal clefts
Images
aortic atherosclerotic plaque Image: https://twitter.com/BeynonMD/status/718292728862400512
cholesterol embolism / cholesterol embolus with cholesterol clefts https://twitter.com/BethBraunhut/status/877208580209999876
Cholesterol crystal clefts and foreing-body giant cells found in radicular cyst https://twitter.com/reportesVilla/status/879410114914136064
See also (...)