Cellular lesions

Articles

• cytoskeletal anomalies
  4 February 2006

  Abnormalities of the cytoskeleton underlie a variety of pathologic states.
  The normal cytoskeleton
  The cytoskeleton consists of microtubules (20 to 25 nm in diameter), thin actin filaments (6 to 8 nm), thick myosin filaments (15 nm), and various classes of intermediate filaments (10 nm). Several other nonpolymerized and nonfilamentous forms of contractile proteins also exist.
  Cytoskeletal abnormalities may be reflected by: (1) defects in cell function, such as cell locomotion and (...)

• sea-blue histiocytes
  18 January 2006

  sea blue histiocytes, histiocytes "bleu de mer", acquired lipidosis of marrow macrophages

• cryptic apoptotic bodies
  18 October 2004

  crypt apoptotic bodies; crypt apoptotic body
  Images
  colorectal GVHD
  https://twitter.com/Pathologists/status/742099178583515137
  https://twitter.com/stephen_lagana/status/736578297153327104
  Histopathology assessment is crucial for the diagnosis of graft versus host disease (GVHD), as the presence of crypt apoptosis is the cardinal criterion required.
  However, crypt apoptosis is not limited to GVHD; it also occurs in other conditions such as infection, drug reaction, or inflammatory (...)

• nuclear inclusions
  4 April 2005

  Definition: Abnormal substances in the nuclei that can be observed by light microscopy are often broadly referred to as nuclear inclusions.
  Images
  Nuclear pseudoinclusions in adrenal cortical adenoma
  https://twitter.com/a_sleeping_dog/status/766154834185641984
  Types
  nuclear pseudoinclusions
  nuclear viral inclusions
  Although their recognition in the appropriate clinicopathological settings can aid in the diagnosis of some disease entities and tumor types, they can also be a (...)

• pseudo-Gaucher cell
  29 December 2006

  pseudo-Gaucher histiocytes, pseudo-Gaucher macrophages

• lipofuscin deposits
  8 January 2006

  Definition: Lipofuscin pigment granules represent undigested material derived from intracellular lipid peroxidation.
  Images
  Lipofuscin is the "wear-and-tear" pigment of the heart. Morphologically found at the myocytes’ nuclear "poles" https://twitter.com/MelanieBoisMD/status/807701991782842369
  Wikimedia: intestinal melanosis
  Localization
  cardiomyocytic lipofuscin deposits
  hepatocytic lipofuscin deposits
  Kupffer cells lipofuscin deposits
  lipofuscin (...)

• epithelial dysplasias
  20 June 2007

  epithelial dysplasia

• epithelial atypia
  9 December 2005

  Definition: Atypia of epithelial cells.
  Synopsis
  nuclear enlargment
  nuclear hyperchromasia
  nuclear pleomorphism
  anisokaryosis
  Etiology
  viral infections (viral cytopathic effect)
  tumoral process (tumoral cells)
  drugs (drug-induced cellular atypia) chemotherapy alkylating agents (cyclophosphamide, busulfan, melphalan)
  Localization
  lungs
  urinary bladder
  sinonasal tract (#11342778#)
  esophagus, stomach,intestines
  pancreas
  cervix
  uterus
  breast : mammary (...)

• cholesterol crystals
  3 December 2005

  cholesterol clefts; Cholesterol crystal clefts
  Images
  aortic atherosclerotic plaque Image: https://twitter.com/BeynonMD/status/718292728862400512
  cholesterol embolism / cholesterol embolus with cholesterol clefts https://twitter.com/BethBraunhut/status/877208580209999876
  Cholesterol crystal clefts and foreing-body giant cells found in radicular cyst https://twitter.com/reportesVilla/status/879410114914136064
  See also (...)

• vacuolated Kuppfer cells
  29 July 2008

  Etiology (Examples)
  galactosialidosis (MIM.256540)

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