CREB1 code for the cAMP response element-binding protein 1.
Functions
Cyclic AMP (cAMP) second messenger pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals.
Following hormonal stimulation of a neuroendocrine cell, for example, increased cAMP levels activate cAMP-dependent protein kinase A, which phosphorylates 1 or more DNA-binding proteins. These in turn stimulate transcription of an array of cAMP-responsive (...)
Home > Keywords > Proteins > Cancer gene
Cancer gene
Articles
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CREB1
29 August 2007 -
ATF2
29 August 2007CREB2, CREBP1
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EML4
23 July 2007Pathology
EML4-ALK fusion gene in non-small-cell lung cancer (6.7% of NSCLC) (#17625570#)
See also
EMLs: EML1, EMl2, EML3
References
Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Jul 11; PMID: #17625570#
Heidebrecht, H. J.; Buck, F.; (...) -
PVRL2
29 August 2007Function
Entry of the poliovirus into permissive cells is dependent on the expression of a specific receptor, the poliovirus receptor (PVR; 173850), which is an integral membrane glycoprotein.
Its extracellular region exhibits 3 immunoglobulin-like domains. Two integral forms, PVR-alpha and PVR-delta, and 2 soluble forms, PVR-beta and PVR-gamma, are lacking a transmembrane region generated by alternative splicing of mRNA. The normal cellular function of PVR is unknown.
Pathology (...) -
SP3
5 November 2007Transcriptional regulation is exerted through protein factors that bind to distinct DNA elements in the vicinity of target genes.
Many control elements are recognized by families of transcription factors, opening combinatorial possibilities to the regulatory interactions. Among the most widely distributed control elements are GC boxes and related motifs bound by Sp1.
Pathology
EWSR1-SP3 fusion gene in undifferentiated small round cell sarcomas (#17690209#)
SPs (SP1 , SP2 , SP3 ) (...) -
PTK2B
28 February 2008protein-tyrosine kinase 2 beta
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HMGA1
29 February 2008HMGI-Y, HMGIY
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CSPG2
28 February 2008Pathology
translocation t(5;8) involving the CSPG2 and PTK2B genes in a dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion (#18253748#)
References
Bianchini L, Maire G, Guillot B, Joujoux JM, Follana P, Simon MP, Coindre JM, Pedeutour F. Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion. Virchows Arch. 2008 Feb 6; PMID: (...) -
IDH1
2 September 2010Immunochemistry
Differentiation of gliomas and reactive gliosis may be challenging both at primary tumor occurrence and at posttherapy biopsy.
The most frequent IDH1 mutation found in the majority of WHO grade II and III gliomas can be visualized with an antibody specifically detecting mutant IDH1 protein.
mIDH1R132H is a tumor-specific marker that is superior to other established markers to differentiate reactive from neoplastic cells in grade II and III gliomas and allows identifying (...) -
KRAS
14 April 2004Ki-ras, KRAS2