Cancer gene

Articles

• NBS1
  19 August 2004

  Pathology
  germline mutations in the Nijmegen breakage syndrome (NBS)
  increased cancer risk of heterozygotes with NBS1 germline mutations (#15185344#)
  See also
  FANC/BRCA1/BRCA2/ATM/NBS1 signaling pathway
  References
  Kobayashi J, Antoccia A, Tauchi H, Matsuura S, Komatsu K. NBS1 and its functional role in the DNA damage response. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):855-61. PMID: (...)

• MAP3K5
  28 June 2004

  ASK1

• KRAS
  14 April 2004

  Ki-ras, KRAS2

• NKX3A
  31 January 2007

  NKX3-1
  Definition: The homeodomain-containing transcription factor NKX3A is a putative prostate tumor suppressor that is expressed in a largely prostate-specific and androgen-regulated manner.
  NKX3.1 is a prostatic tumor suppressor gene located on chromosome 8p.
  Although most studies have shown that staining for NKX3.1 protein is positive in the majority of primary prostatic adenocarcinomas, it has been shown to be downregulated in many high-grade prostate cancers, and completely lost in (...)

• ERBB2
  11 February 2006

  ERBB2 ; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1; c-erbb2
  The oncogene originally called HER/NEU was derived from rat neuro/glioblastoma cell lines. It encodes a tumor antigen, p185, which is serologically related to EGFR, the epidermal growth factor receptor (MIM.131550).
  ERBB2 encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases (ERBBs).
  ERBB2 has no ligand binding domain of its own and therefore cannot bind growth factors. (...)

• STK11
  29 October 2003

  XEEK1, LKB1
  Definition: STK11 (LKB1) is a serine-threonine protein kinase mutated in patients with an autosomal dominantly inherited cancer syndrome predisposing to multiple benign and malignant tumours, termed Peutz-Jeghers syndrome.
  LKB1 has been implicated as a regulator of multiple biological processes and signaling pathways, including the control of cell-cycle arrest, p53-mediated apoptosis, Wnt signaling, transforming growth factor (TGF)-beta signaling, ras-induced cell (...)

• MADH3
  10 November 2003

  SMAD3
  Pathology
  EWSR1-MADH3 / SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms. (#29309308#) https://twitter.com/ScottBikeethan/status/1150821877386027008
  References
  Novel EWSR1-SMAD3 Gene Fusions in a Group of Acral Fibroblastic Spindle Cell Neoplasms. Kao YC, Zhang L, Sung YS, Suurmeijer AJH, Antonescu CR. Am J Surg Pathol. 2018 Jan 5. doi:10.1097/PAS.0000000000001002. PMID: #29309308#
  Roberts AB, Russo A, Felici A, Flanders KC. Smad3: a key player in (...)

• CREB1
  29 August 2007

  CREB1 code for the cAMP response element-binding protein 1.
  Functions
  Cyclic AMP (cAMP) second messenger pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals.
  Following hormonal stimulation of a neuroendocrine cell, for example, increased cAMP levels activate cAMP-dependent protein kinase A, which phosphorylates 1 or more DNA-binding proteins. These in turn stimulate transcription of an array of cAMP-responsive (...)

• CDK5RAP2
  3 April 2005

  Pathology
  germline mutations in primary autosomal recessive microcephaly type 3 (MIM.604804)
  CDK5RAP2/PDGFRA fusion gene by ins(9;4)(q33;q12q25) in chronic eosinophilic leukemia (#16845659#)
  References
  Walz C, Curtis C, Schnittger S, Schultheis B, Metzgeroth G, Schoch C, Lengfelder E, Erben P, Muller MC, Haferlach T, Hochhaus A, Hehlmann R, Cross NC, Reiter A. Transient response to imatinib in a chronic eosinophilic leukemia associated with ins(9;4)(q33;q12q25) and a CDK5RAP2-PDGFRA (...)

• MYCN
  18 April 2005

  NMYC, N-MYC

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