Cancer gene

Articles

• CREB1
  29 August 2007

  CREB1 code for the cAMP response element-binding protein 1.
  Functions
  Cyclic AMP (cAMP) second messenger pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals.
  Following hormonal stimulation of a neuroendocrine cell, for example, increased cAMP levels activate cAMP-dependent protein kinase A, which phosphorylates 1 or more DNA-binding proteins. These in turn stimulate transcription of an array of cAMP-responsive (...)

• ATF2
  29 August 2007

  CREB2, CREBP1

• EML4
  23 July 2007

  Pathology
  EML4-ALK fusion gene in non-small-cell lung cancer (6.7% of NSCLC) (#17625570#)
  See also
  EMLs: EML1, EMl2, EML3
  References
  Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S, Fujiwara SI, Watanabe H, Kurashina K, Hatanaka H, Bando M, Ohno S, Ishikawa Y, Aburatani H, Niki T, Sohara Y, Sugiyama Y, Mano H. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature. 2007 Jul 11; PMID: #17625570#
  Heidebrecht, H. J.; Buck, F.; (...)

• PVRL2
  29 August 2007

  Function
  Entry of the poliovirus into permissive cells is dependent on the expression of a specific receptor, the poliovirus receptor (PVR; 173850), which is an integral membrane glycoprotein.
  Its extracellular region exhibits 3 immunoglobulin-like domains. Two integral forms, PVR-alpha and PVR-delta, and 2 soluble forms, PVR-beta and PVR-gamma, are lacking a transmembrane region generated by alternative splicing of mRNA. The normal cellular function of PVR is unknown.
  Pathology (...)

• SP3
  5 November 2007

  Transcriptional regulation is exerted through protein factors that bind to distinct DNA elements in the vicinity of target genes.
  Many control elements are recognized by families of transcription factors, opening combinatorial possibilities to the regulatory interactions. Among the most widely distributed control elements are GC boxes and related motifs bound by Sp1.
  Pathology
  EWSR1-SP3 fusion gene in undifferentiated small round cell sarcomas (#17690209#)
  SPs (SP1 , SP2 , SP3 ) (...)

• PTK2B
  28 February 2008

  protein-tyrosine kinase 2 beta

• HMGA1
  29 February 2008

  HMGI-Y, HMGIY

• CSPG2
  28 February 2008

  Pathology
  translocation t(5;8) involving the CSPG2 and PTK2B genes in a dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion (#18253748#)
  References
  Bianchini L, Maire G, Guillot B, Joujoux JM, Follana P, Simon MP, Coindre JM, Pedeutour F. Complex t(5;8) involving the CSPG2 and PTK2B genes in a case of dermatofibrosarcoma protuberans without the COL1A1-PDGFB fusion. Virchows Arch. 2008 Feb 6; PMID: (...)

• IDH1
  2 September 2010

  Immunochemistry
  Differentiation of gliomas and reactive gliosis may be challenging both at primary tumor occurrence and at posttherapy biopsy.
  The most frequent IDH1 mutation found in the majority of WHO grade II and III gliomas can be visualized with an antibody specifically detecting mutant IDH1 protein.
  mIDH1R132H is a tumor-specific marker that is superior to other established markers to differentiate reactive from neoplastic cells in grade II and III gliomas and allows identifying (...)

• KRAS
  14 April 2004

  Ki-ras, KRAS2

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