Cancer gene

Articles

• MNX1
  8 December 2004

  HLXB9; HB9, HOXHB9, SCRA1; "homeo box HB9", "homeobox HB9"; motor neuron and pancreas homeobox 1

• STAT3
  29 November 2004

  signal transducer and activator of transcription 3 (acute-phase response factor)

• ESR1
  12 December 2003

  ER-alpha, estrogen receptor alpha

• PDGFRA
  12 December 2003

  platelet-derived growth factor receptor (PDGFR) alpha, PDGFR-alpha

• KIT
  12 December 2003

  c-kit; CD117
  Definition: The proto-oncogene c-kit / CC117 is a receptor tyrosine kinase recognized to initiate essential signal transduction pathways that transmit biological signals for cellular proliferation, differentiation, and metastasis. Aberrant expression or mutation of c-kit has been shown to be involved in the pathogenesis of many cancers. See also CD117 IHCDB
  Expression in cells
  c-KIT positive spermatogonia
  Expression in tumors (Exemples)
  chromophobe renal cell (...)

• FLCN
  27 November 2004

  folliculin, FLCL

• GAB2
  14 September 2007

  Chromosome arm 11q amplifications involving the mixed lineage leukemia gene (MLL) locus are rare but recurrent aberrations in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). GAB2 is a novel target of 11q amplification in AML/MDS.
  In addition to the MLL core amplicon, independent sequences in 11q23-24 and/or 11q13.5 are coamplified within the same cytogenetic markers in 90% and 60% of patients, respectively.
  The minimal amplicon in 11q13.5 measures 1.17 Mb.
  Pathology
  The (...)

• FOXO3A
  7 October 2005

  FKHRL1, AF6q21

• AKT2
  2 February 2007

  Definition: AKT2 (MIM.164731) is the isoform of AKT 1 and is enriched in insulin-responsive tissues and has been implicated in the metabolic actions of the hormone.
  Pathology
  An activating mutation of AKT2 and human hypoglycemia. (#21979934#)
  AKT2 mutations and/or amplification in tumors ovarian carcinomas (#16839745#, #16721043#) pancreatic carcinomas (#14735903#) mammary carcinomas (#12032855#) embryonal rhabdomyosarcoma (#16790082#)
  See also
  AKTs
  References
  An activating (...)

• EMS1
  31 January 2007

  cortactin,

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