Involved in translocations

Articles

• PAX8
  5 July 2004

  Definition: PAX8 is a paired-box gene important in embryogenesis of the thyroid, Müllerian tract, and renal/upper urinary tracts.
  Images
  FNA of extraovarian primary peritoneal carcinoma metastatic to supraclavicular lymphnode ER+ PAX8+
  https://twitter.com/pathologyfinder/status/768395560562876416
  Function
  Pax8 is a transcription factor associated with the embryonic development of the thyroid gland, kidney, and the Müllerian system and plays a role in the tumorigenesis of these organs. (...)

• FOX01A
  25 November 2003

  FKHR

• CAMTA1
  1 June 2007

  Definition: CAMTA1 (calmodulin-binding transcription activator 1) gene spans a minimal region of 1p36 loss in gliomas with oligodendrial differentiation but is not subject to somatic mutations. CAMTA1 expression is cell cycle dependent, being higher in the S and M phases. CAMTA1 is a putative 1p36 cancer gene.
  Pathology
  A WWTR1-CAMTA1 gene fusion is a consistent abnormality in epithelioid hemangioendothelioma of different anatomic sites. (#21584898#)
  Epithelioid hemangioendothelioma (...)

• NAB2
  9 September 2015

  WKP
  Pathology
  NAB2-STAT6 gene fusion NAB2-STAT6 gene fusion in solitary fibrous tumor (SFT) (#26337721#) Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing. (#23313952#, #23313954#)
  Open references
  A GRIA2 and PAX8-positive renal solitary fibrous tumor with NAB2-STAT6 gene fusion. Ichiyanagi O, Ito H, Takai S, Naito S, Kato T, Nagaoka A, Yamakawa M. Diagn Pathol. 2015 Sep 4;10(1):155. doi:10.1186/s13000-015-0386-x . PMID: (...)

• CDX2
  15 December 2003

  CDX-2

• IRF4
  28 October 2009

  MUM1 PO
  Expression in normal cells and functions
  Transcriptional factor (MUM1/IRF4, MUltiple Myeloma 1 / Interferon Regulatory Factor 4 protein) is expressed in final step of intra-germinal center B cell differentiation and in post-germinal center (late centrocyte) B cells (Blood 2000;95:2084, Appl Immunohistochem Mol Morphol 2010;18:301).
  Antigen stimulated B cells with the capacity to differentiate toward plasma cells express MUM1/IRF4.
  Expression in B cells (some) and plasma (...)

• MALAT1
  26 June 2007

  metastasis-associated lung adenocarcinoma transcript 1

• MAML2
  8 March 2004

  Mastermind-like Notch coactivator MAML2
  Pathology
  MAML2-MECT1 (MAMl2-CRTC1) gene fusion by t(11;19)(q21;p13) in
  mucoepidermoid carcinoma (#14720503#)
  benign Warthin tumor (#14720503#)
  cutaneous clear cell hidradenoma (#15729701#, #17334997#)
  MAML2-WAMTP1 gene fusion
  MAML2-MLL gene fusion in
  secondary acute myelogenous leukemia (#17551948#)
  myelodysplastic syndrome with inv(11)(q21q23) (#17551948#)
  The MECT1-MAML2 translocation is identified in a large proportion of (...)

• ATF1
  14 October 2003

  ATF-1

• RET
  12 November 2003

  MIM.164761, Locus: 10q11.2
  Pathology
  germline mutations mutations in Hirschsprung disease mutations in MEN2A
  *-* RET634: association MENA-renal dysplasia (#12606135#) mutations in MEN2B mutations in familial medullary thryoid carcinoma (FMTC) mutations in unilateral renal agenesis (#11454140#) mutations in congenital central hypoventilation syndrome (CCHS) (MIM.209880) isolated or with total colonic aganglionosis
  fusion gene in papillary thyroid carcinomas (PTC) RET/PTC1 (papillary (...)

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