Protein family

Articles

• CRYGs
  15 May 2005

  Members CRYGA CRYGD CRYGS
  Pathology
  germline mutations in cataracts

• CRYBs
  15 May 2005

  Members CRYB1 CRYB2 CRYB3 CRYB4
  See also
  CRYs CRYAs CRYBs CRYGs

• CRYAs
  15 May 2005

  Memebrs CRYAA CRYAB
  See also
  CRYs CRYAs CRYBs CRYGs

• GATAs
  24 May 2005

  Definition: The GATA-binding proteins (GATAs) are a group of structurally related transcription factors that control gene expression and differentiation in a variety of cell types.
  Members of the GATAs family of DNA-binding proteins recognize a consensus sequence known as the ’GATA’ motif, which is an important cis-element in the promoters of many genes. All GATA-binding proteins contain 1 or 2 zinc finger motifs of the distinctive form CXNCX(17)CNXC.
  Members GATA1 GATA2 GATA3 GATA4 (...)

• CHXs
  14 May 2005

  Members CHX1 CHX2 CHX3 CHX4 CHX5 CHX6 CHX7 CHX8 CHX9 CHX10
  See also
  transcription factors

• DSCs
  14 July 2003

  desmocollins

• GJs
  14 July 2003

  CX, GAP junction proteins (GJs), connexins

• SMCs
  30 April 2007

  Structural maintenance of chromosomes proteins, SMC proteins

• MYCs
  28 June 2004

  Members MYC MYCN MYCL1
  HIF-MYC interactions
  The interaction of MYC and hypoxia inducible factors (HIFs) under physiological, non-tumorigenic conditions provides insights into normal homeostatic cellular responses to low oxygen levels (hypoxia).
  Many tumours contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumour cells, which tend to exist in a hypoxic microenvironment.
  References
  Dang CV, Kim JW, Gao P, Yustein (...)

• RUNXs
  28 June 2004

  Definition: RUNX transcription factors (RUNXs) are key regulators of lineage-specific gene expression and might be involved in autoimmune diseases.
  Members RUNX1 RUNX2 RUNX3 RUNX4
  References
  Blyth K, Cameron ER, Neil JC. The runx genes: gain or loss of function in cancer. Nat Rev Cancer. 2005 May;5(5):376-87. PMID: #15864279#
  Ito Y. Oncogenic potential of the RUNX gene family: ’overview’. Oncogene. 2004 May 24;23(24):4198-208. PMID: #15156173#
  Anglin I, Passaniti A. Runx protein (...)

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