Protein family

Articles

• IDs
  26 August 2004

  Id proteins
  ID proteins contain a helix-loop-helix (HLH) motif and regulate tissue-specific transcription within several cell lineages. They do not bind DNA directly, but inhibit lineage commitment by binding basic helix-loop-helix (bHLH) transcription factors through their HLH motif. ID proteins contribute to cell growth, senescence, differentiation, angiogenesis, invasion and migration.
  Members ID1 ID2 ID3 ID4
  See also
  HLH proteins : HLHs
  References
  Perk J, Iavarone A, (...)

• WASFs
  24 August 2004

  WAVEs

• WNTs
  13 July 2003

  Wnt family proteins
  Definition: The WNTs are a family of secreted glycoproteins that have been shown to be involved in a variety of developmental processes in many organisms. The WNT gene family consists of structurally related genes that encode cysteine-rich secreted glycoproteins that act as extracellular signaling factors.
  The WNT gene family (WNTs) consists of structurally related genes encoding secreted signaling molecules that have been implicated in oncogenesis and in several (...)

• aminoacyl-tRNA synthetases
  13 July 2003

  Definition: Aminoacyl-tRNA synthetases attach aminoacids to their cognate tRNA.
  Functions
  Aminoacyl-tRNA synthetases attach aminoacids to their cognate tRNA.
  Aminoacyl-tRNA synthetases perform an essential function in protein synthesis by catalyzing the esterification of an amino acid to its cognate tRNA. These enzymes are necessarily present in each cell and must properly recognize the tRNA and the amino acid in order to maintain fidelity of translation.
  From the primary structures, 2 (...)

• CALBs
  7 July 2004

  Calbindins are calcium-binding proteins belonging to the troponin C superfamily (MIM.191040).
  Members CALB1 CALB2

• MYLs
  7 July 2004

  myosin light chains

• PTPNs
  7 July 2004

  Family of nonreceptor protein tyrosine phosphatases. PTPN1 PTPN2 PTPN3 PTPN4 PTPN5 PTPN6 PTPN7 PTPN8 PTPN9 PTPN10 PTPN11 PTPN12 PTPN13 PTPN14 PTPN15 PTPN16 PTPN17 PTPN18 PTPN19 PTPN20 PTPN21 PTPN22
  Pathology PTPN11 Noonan syndrome mutation PTPN11 LEOPARD syndrome mutation PTPN22 Rheumatoid Arthritis SNP association

• MYHs
  7 July 2004

  myosin heavy chains

• POUs
  13 July 2004

  Transcription factors containing the POU homeodomain
  Functions
  Transcription factors containing the POU homeodomain have been shown to be important regulators of tissue-specific gene expression in lymphoid and pituitary differentiation and in early mammalian development.
  Members POU1s POU2s POU3s POU4s POU5s
  Pathology
  POU1F1 germline mutations in combined pituitary hormone deficiency (...)

• RUNXs
  28 June 2004

  Definition: RUNX transcription factors (RUNXs) are key regulators of lineage-specific gene expression and might be involved in autoimmune diseases.
  Members RUNX1 RUNX2 RUNX3 RUNX4
  References
  Blyth K, Cameron ER, Neil JC. The runx genes: gain or loss of function in cancer. Nat Rev Cancer. 2005 May;5(5):376-87. PMID: #15864279#
  Ito Y. Oncogenic potential of the RUNX gene family: ’overview’. Oncogene. 2004 May 24;23(24):4198-208. PMID: #15156173#
  Anglin I, Passaniti A. Runx protein (...)

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