Protein family

Articles

• E2Fs
  31 May 2006

  Members E2F1 E2F2 E2F3 E2F4 E2F5 E2F6
  See also
  transcription factors
  References
  DeGregori J, Johnson DG. Distinct and Overlapping Roles for E2F Family Members in Transcription, Proliferation and Apoptosis. Curr Mol Med. 2006 Nov;6(7):739-48. PMID: #17100600#
  Johnson DG, Degregori J. Putting the Oncogenic and Tumor Suppressive Activities of E2F into Context. Curr Mol Med. 2006 Nov;6(7):731-8. PMID: (...)

• HIFs
  31 May 2006

  Hypoxia-inducible factors (HIFs)

• CDHs
  28 May 2003

  Cadherin superfamily, cadherins

• GDIs
  5 June 2006

  Rab escort proteins (REPs) and Rab GDP-dissociation inhibitor (GDIs) mediate membrane association of Rab proteins.
  Members GDI1 GDI2
  REPs and CDIs cycle
  Rab proteins are intrinsically soluble and require the post-translational covalent attachment of isoprenoid moieties to their C-termini for membrane association. Newly synthesized Rabs associate with REP and form a stable complex.
  The complex is a substrate for the heterodimeric Rab geranylgeranyl transferase (RabGGT), which (...)

• SUMOs
  23 January 2008

  The small ubiquitin-like modifiers (SUMOs) are involved in many cellular processes and is required for normal growth and development in all eukaryotes.
  Whereas lower eukaryotes have a single version of SUMO, higher eukaryotes have three versions: SUMO1, SUMO2 and SUMO3.
  Similarly to most other ubiquitin-like proteins, the primary translation products of the SUMO genes need to be proteolytically processed to expose the C-terminal glycine that will be linked to lysine side chains in (...)

• GHRHs
  25 January 2008

  GnRH

• TFFs
  28 January 2008

  Trefoil factors (TFFs)

• carbonic anhydrases
  21 January 2008

  Carbonic anhydrases (CAs) is a group of ubiquitously expressed metalloenzymes.
  They are involved in numerous physiological and pathological processes, including gluconeogenesis, lipogenesis, ureagenesis, tumorigenicity and the growth and virulence of various pathogens.
  In addition to the established role of CA inhibitors (CAIs) as diuretics and antiglaucoma drugs, it has recently emerged that CAIs could have potential as novel anti-obesity, anticancer and anti-infective drugs. (...)

• TNs
  9 January 2006

  tenascins

• H1s
  7 January 2005

  The family of H1 histone genes (H1s) in man and mouse consists of 7 different subtypes, the main type histone genes H1.1 through H1.5, the testis-specific variant H1T, and the replacement subtype H1(0).
  All known human H1 genes clustered on the short arm of chromosome 6, whereas the gene for the replacement variant H1(0) is solitarily located on chromosome 22.
  The histone genes on the short arm of chromosome 6 are organized into 2 clusters. The major cluster at 6p22-p21.3 contains 32 (...)

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