Home > E. Pathology by systems > Locomotory system > Bones > adamantinoma


Wednesday 14 June 2006


Digital cases

- JRC:4309 : Adamantinoma (Bone; 37 y/o male).
- JRC:900 : Adamantinoma (Bone (tibia and fibula); 29 y/o male).
- JRC:3170 : Classic adamantinoma (Bone: tibia).
- JRC:15204 : Adamantinoma? (Bone: leg / Diff DX: Monophasic synovial sarcoma?).
- JRC:19170 : Adamantinoma? (Bone: leg / Diff DX: Monophasic synovial sarcoma?).


- adamantinoma of long bones


- differentiated adamantinoma (osteofibrous dysplasia-like adamantinoma)


- trisomy 7
- trisomy 8
- trisomy 12
- trisomy 19
- tumoral trisomy 21


It has been surmised that osteofibrous dysplasia (OFD) (ossifying fibroma) and adamantinoma are on a continuum with osteofibrous dysplasia-like adamantinoma representing an intermediate step between the two lesions.

Findings indicate that osteofibrous dysplasia, differentiated adamantinoma, and adamantinoma, should be regarded as related conditions.

However, only rarely does a case of osteofibrous dysplasia or differentiated adamantinoma eventually act in a malignant fashion.

Genetic studies have also pointed to a relationship between OFD and adamantinoma in that the tumors have been found to share recurrent trisomies (chromosomes 7, 8, 12, and 21).

See also

- Tumors

  • osseous tumors


- Kanamori M, Antonescu CR, Scott M, Bridge RS Jr, Neff JR, Spanier SS, Scarborough MT, Vergara G, Rosenthal HG, Bridge JA. Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma. J Mol Diagn. 2001 Feb;3(1):16-21. PMID: 11227067