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Monday 29 September 2003

BRCA1 and BRCA2 contribute to homologous recombination and DNA repair, to embryonic proliferation, to transcriptional regulation and, for BRCA1, to ubiquitination.


- germline mutationso of BRCA2 in

  • high risks of breast and ovarian cancer
  • Fanconi syncrome (Fanconi anemia - FA)

- somatic mutations of BRCA2 in

  • medulloblastoma


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- Venkitaraman AR. Tracing the network connecting BRCA and Fanconi anaemia proteins. Nat Rev Cancer. 2004 Apr;4(4):266-76. PMID: 15057286

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- Wang SC, Shao R, Pao AY, Zhang S, Hung MC, Su LK. Inhibition of cancer cell growth by BRCA2. Cancer Res. 2002 Mar 1;62(5):1311-4. PMID: 11888897

- Welcsh PL, King MC. BRCA1 and BRCA2 and the genetics of breast and ovarian cancer. Hum Mol Genet. 2001 Apr ;10(7):705-13. PMID : 11257103

- Welcsh PL, Owens KN, King MC. Insights into the functions of BRCA1 and BRCA2. Trends Genet. 2000 Feb;16(2):69-74. PMID: 10652533

- Stratton MR. Recent advances in understanding of genetic susceptibility to breast cancer. Hum Mol Genet. 1996;5 Spec No:1515-9. PMID: 8875258

- Pellegrini, L.; Yu, D. S.; Lo, T.; Anand, S.; Lee, M.; Blundell, T. L.; Venkitaraman, A. R. :
Insights into DNA recombination from the structure of a RAD51-BRCA2 complex. Nature 420: 287-293, 2002.
PubMed ID : 12442171