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trans-Golgi network

Saturday 3 June 2006

The trans-Golgi network (TGN) is a major sorting centre for cell lipids and proteins at the crossroads of the endocytic and exocytic pathways; it has a complex dynamic structure composed of a network of tubular membranes that generate pleiomorphic carriers targeted to different destinations.

The composition and identity of cell organelles are dictated by the flux of lipids and proteins that they receive and lose through cytosolic exchange and membrane trafficking.

See also

- Golgi apparatus

References

- De Matteis MA, Luini A. Exiting the Golgi complex. Nat Rev Mol Cell Biol. 2008 Apr;9(4):273-84. PMID: #18354421#

- Bonifacino JS, Rojas R. Retrograde transport from endosomes to the trans-Golgi network. Nat Rev Mol Cell Biol. 2006 Aug;7(8):568-79. PMID: #16936697#

- Traub LM, Kornfeld S. The trans-Golgi network: a late secretory sorting station. Curr Opin Cell Biol 1997;9:527-53

- Shields D, Arvan P. Disease models provide insights into post-Golgi protein trafficking, localization and processing. Curr Opin Cell Biol 1999;11:489-494