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attention-deficit/hyperactivity disorder

MIM.143465

Monday 29 September 2003

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology.

Etiology

- Rare recurrent CNVs affecting glutamatergic neurotransmission genes

  • GRM5 (encoding glutamate receptor, metabotropic 5) deletions
  • GRM7 deletions
  • GRM8 deletions
  • GRM1 duplication

Susceptibility loci

- 4q13.2 (#15497111#)
- 5p13 (#12687500#)
- 5q33.3 (#15497111#)
- 6q12 (#15297934#)
- 7p (#12679898#)
- 11q22 (#15497111#)
- 15q (#12679898#)
- 16p13 (also involved in autism) (#12187510#)
- 17p11 (#12687500#, #15497111#)

Reviews

- Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci. 2002 Aug;3(8):617-28. PMID: #12154363#

References

- Genome-wide copy number variation study associates metabotropic glutamate receptor gene networks with attention deficit hyperactivity disorder. Elia J, Glessner JT, Wang K, Takahashi N et al. Nat Genet. 2011 Dec 4;44(1):78-84. PMID: #22138692#