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splenic littoral cell angioma

Thursday 20 April 2006

Synopsis

- minute foci to large nodules almost completely replacing the splenic tissue
- anastomosing vascular channels resembling splenic sinus
- irregular lumina
- papillary projections
- cyst-like spaces
- lined by tall endothelial cells that slough off into the vascular lumina and show hemophagocytosis
- atypical cells absent
- mitotic activity very low

Immunochemistry

- neoplastic cells express both endothelial (FVIII-AG, BMA 120) and histiocytic (KP1, lysozyme) antigens
- +/- S-100 +

References

- Metastasizing splenic littoral cell hemangioendothelioma. Fernandez S, Cook GW, Arber DA. Am J Surg Pathol. 2006 Aug;30(8):1036-40. PMID: 16861977

- Falk S, Stutte HJ, Frizzera G. Littoral cell angioma. A novel splenic vascular lesion demonstrating histiocytic differentiation. Am J Surg Pathol. 1991 Nov;15(11):1023-33. PMID: 1928554