Home > D. Systemic pathology > Genetic and developmental anomalies > Chromosomal diseases > Constitutional deletions > ring chromosomes

ring chromosomes

Sunday 19 March 2006

A ring chromosome is a special form of deletion. It is produced when a break occurs at both ends of a chromosome with fusion of the damaged ends.

If significant genetic material is lost, phenotypic abnormalities result. This might be expressed as 46,XY,r(14).

Ring chromosomes do not behave normally in meiosis or mitosis and usually result in serious consequences.