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SNAI2

MIM.602150 8q11 HGNC:11094

Saturday 18 March 2006

SLUG; WS2D; SLUGH1; MGC10182; SNAI2

Definition: Slug encodes a member of the Snail family of C2H2-type zinc finger transcription factors.

The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma.

SNAI2 (SLUG) protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.

Mutations in this gene may be associated with sporatic cases of neural tube defects.

The expression of E-cadherin correlates with the progression and metastasis of gastric cancer.

Pathology

SNAI2 (SLUG) mutations imay be associated with sporadic cases of neural tube defects.

- germline mutations

Immunochemistry

- Increased Slug and decreased E-cadherin (CDH1) expression is related to poor prognosis in patients with gastric cancer. (21274735)

  • Evaluation of not only the expression of E-cadherin (CDH1), but also the coexpression of E-cadherin and Slug in patients with preserved E-cadherin expression would be useful for predicting malignant properties of gastric cancer. (21274735)

See also

- SNAIs (SNAILs)

  • SNAI1

References

- Biological roles and prognostic values of the epithelial-mesenchymal transition-mediating transcription factors Twist, ZEB1 and Slug in diffuse large B-cell lymphoma. Lemma S, Karihtala P, Haapasaari KM, Jantunen E, Soini Y, Bloigu R, Pasanen AK, Turpeenniemi-Hujanen T, Kuittinen O. Histopathology. 2012 Jul 26. PMID: 23190132

- Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer. Uchikado Y, Okumura H, Ishigami S, Setoyama T, Matsumoto M, Owaki T, Kita Y, Natsugoe S. Gastric Cancer. 2011 Jan 28. PMID: 21274735

- Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer. 2007 Jun;7(6):415-28. PMID: 17508028