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glycosphingolipid

Saturday 11 March 2006

Definition: Glycosphingolipids are ceramides with one or more sugar residues joined in a β-glycosidic linkage at the 1-hydroxyl position. Glycosphingolipids may be further subdivided into cerebrosides and gangliosides. Cerebrosides have a single glucose or galactose at the 1-hydroxy position, while gangliosides have at least three sugars, one of which must be sialic acid.

Glycosphingolipids are a subtype of glycolipids containing the amino alcohol sphingosine (as a subgroup of sphingolipids).

Types

- cerebrosides (glucocerebroside and galactocerebroside)
- gangliosides
- globosides
- sulfatides
- glycophosphosphingolipids

See also

- Lipids

References

- Sillence DJ, Platt FM. Glycosphingolipids in endocytic membrane transport. Semin Cell Dev Biol. 2004 Aug;15(4):409-16. PMID: 15207831

- Sillence DJ, Platt FM. Storage diseases: new insights into sphingolipid functions. Trends Cell Biol. 2003 Apr;13(4):195-203. PMID: 12667757