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renal tubular morphogenesis

Tuesday 28 February 2006

Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells.

Renal tubulogenesis

- Lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization

- Mitotic orientations are significantly distorted in rodent polycystic kidney models. Oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.

See also

- morphogenesis
- renal tubulogenesis

References

- Fischer E, Legue E, Doyen A, Nato F, Nicolas JF, Torres V, Yaniv M, Pontoglio M. Defective planar cell polarity in polycystic kidney disease. Nat Genet. 2006 Jan;38(1):21-3. PMID: 16341222

- Affolter M, Bellusci S, Itoh N, Shilo B, Thiery JP, Werb Z. Tube or not tube: remodeling epithelial tissues by branching morphogenesis. Dev Cell. 2003 Jan;4(1):11-8. PMID: 12530959