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giant cell tumor of soft tissue

ICD-O:9251/1

Friday 24 February 2006

GCTST is predominantly seen in adults and typically shows uniformly dispersed osteoclast-like giant cells admixed with oval to polygonal mononuclear cells.

It usually follows a benign clinical course, although the malignant variant has been described in cases in which the mononuclear cells demonstrate obvious dysplastic features.

These lesions occur most often in skin or subcutis of older adults and the majority pursue an entirely benign clinical course.

However, rare cases may metastasize in an unpredictable fashion, just as with giant cell tumour of bone.

Morphologically, these lesions are characterized by a multinodular growth pattern, often with quite prominent stromal haemorrhage, and bear a close resemblance to giant cell tumour of bone.

Evolution

- rare metastases

Cytogenetics

- telomeric association involving multiple chromosomes (16328671)

References

- The evolving classification of soft tissue tumours: an update based on the new WHO classification. Fletcher CD. Histopathology. 2006 Jan;48(1):3-12. PMID: 16359532

- Guo H, Garcia RA, Perle MA, Amodio J, Greco MA. Giant cell tumor of soft tissue with pulmonary metastases: pathologic and cytogenetic study. Pediatr Dev Pathol. 2005 Nov-Dec;8(6):718-24. PMID: 16328671