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Monday 13 February 2006

The mammalian telencephalon exhibits an amazing diversity of neuronal types. The generation of this diversity relies on multiple developmental strategies, including the regional patterning of progenitors, their temporal specification, and the generation of intermediate progenitor populations. Progress has recently been made in characterizing some of the mechanisms involved.

Intermediate progenitors have been shown to play important roles in the generation of neurons in the cerebral cortex, and the properties and lineage relationships between radial glial cells and these intermediate progenitors have recently been examined by elegant time-lapse microscopic studies.

Multiple pathways control the progression of neural lineages from multipotent stem cells to intermediate progenitors, postmitotic precursors and finally mature neurons.

The regulation of two essential steps, neuronal commitment and specification of subtype identities, is increasingly well understood.

These two steps are clearly distinct but co-ordinately regulated by common transcription factors such as neurogenins and PAX6.


- Guillemot F. Cellular and molecular control of neurogenesis in the mammalian telencephalon. Curr Opin Cell Biol. 2005 Dec;17(6):639-47. Epub 2005 Oct 13. PMID: 16226447