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Leydig cell tumor

Monday 13 February 2006

Digital cases

- HPC:119 : Leydig cell tumor.
- JRC:18782 : Testis intestitial cell tumor

Synopsis

- Leydig cell proliferation

  • round cell proliferation
  • fusiform cell proliferation

- Leydig cells

  • abundant eosinophilic cytoplasm
  • characteristic nuclear-rich zones separated by nuclear-free zones
  • crystals of Reinke (Reinke crystals)

Localization

- ovarian Leydig cell tumor
-  testicular Leydig cell tumor (Leydig cell tumor of the testis)

  • paratesticular Leydig cell tumor

Variants

- microcystic Leydig cell tumor (10328086)

Differential diagnosis

- yolk sac tumor (10328086)

See also

- Sertoli-stromal cell tumors

References

- Billings SD, Roth LM, Ulbright TM. Microcystic Leydig cell tumors mimicking yolk sac tumor: a report of four cases. Am J Surg Pathol. 1999 May;23(5):546-51. PMID: 10328086

- Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors. Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM. Am J Surg Pathol. 1998 Nov;22(11):1361-7. PMID: 9808128

Portfolio

  • Multiple Leydig cell and Sertoli cell adenomas in androgen insentivity (...)
  • Multiple Leydig cell and Sertoli cell adenomas in androgen insentivity (...)
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Ovarian Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor
  • Paratesticular Leydig cell tumor - Cytokeratin -
  • Paratesticular Leydig cell tumor - Inhibin +
  • Paratesticular Leydig cell tumor - Inhibin +
  • Paratesticular Leydig cell tumor - Ki67 -
  • Paratesticular Leydig cell tumor - Vimentin +